Relación entre bienestar espiritual, calidad de vida y sentido del sufrimiento en una población de ancianos religiosos residentes en centros españoles / Relation between spiritual wellbeing, quality of life and sense of suffering in a population of eldery religious resident in Spanish centres

Objetivo: Analizar la relación entre el bienestar espiritual, la satisfacción con la calidad de vida, el estado funcional y el sentido del sufrimiento de una población de religiosos ancianos residentes. Método: Estudio descriptivo, correlacional y transversal. La muestra fue de N = 435 residentes (media de 83,17 años, DT = 7,04). Se utilizaron las escalas FACIT Sp Ex, Humanizar sobre el sentido del sufrimiento, Filadelfia de Lawton e índice de Barthel. Se calcularon la t de Student y correlaciones de Pearson. Resultados: Existe un alto porcentaje (42,3%, N = 88) de residentes insatisfechos con su calidad de vida en la vejez. La media del sentido del sufrimiento como cambio (M = 3,62) fue significativamente (p < 0,05) mayor que como carga (M = 2,36), que mostró correlación significativa (p < 0,01) moderada y positiva con todas las dimensiones del bienestar espiritual (r = 0,276), bienestar general (r = 0,315) y propósito/paz (r = 0,343). El grupo de independencia (según el índice de Barthel) obtuvo una media significativamente mayor (p < 0,05) en las dimensiones paz y propósito (M = 26,28), bienestar general (M = 40,36), bienestar espiritual (M = 78,29) y actitudes hacia la vejez (M = 2,72) que el grupo de dependencia (M = 24,45, M = 38,07, M = 74,63 y M = 2,25, respectivamente). Conclusión: La atención a mayores debe incluir el plano espiritual. El sentido de sufrimiento como carga explicita la transformación interior que la población de religiosos puede dar al sufrimiento. Se destaca la importancia de fomentar la satisfacción con las relaciones sociales y actitudes positivas hacia la vejez, ya que genera bienestar, reduce los niveles de ansiedad y evita la insatisfacción derivada de miedos ante el hecho de hacerse mayor

Objective: To analyze the relationship between spiritual wellbeing, quality of life satisfaction, functional status, and sense of the suffering in a population of religious elderly residents. Methods: Descriptive, transversal and correlational study. The sample included N=435 residents (average age=83.17, SD=7.04). FACIT Sp Ex scale, Sense of Suffering Humannizing scale, Lawton's Philadelphia scale and Barthel's Index were used. Student's T and Pearson's correlations were obtained. Results: There is a high percentage (42.3 %, N=88) of unsatisfied residents with quality of life in the oldness. The average of sense of suffering as change (M=3.62) was significantly (p<.05) greater than as a charge (M=2.36), which showed moderate and positive significant correlation (p<.01) with all dimensions of spiritual well-being (r=.276), overall well-being (r=.315) and purpose/ peace (r=.343). Independence group (according to Barthel index) earned a significantly higher average (p <.05) in dimensions peace and purpose (M=26.28), overall well-being (M=40.36), spiritual well-being (M=78.29) and attitudes towards old age (M=2.72) than dependence group (M=24.45, M=38.07, M=74.63 and M=2.25 respectively). Conclusions: Elderly care must include the spiritual dimension. The sense of suffering as a charge explicits inner transformation that religious population can give to the suffering. It is highlighted the importance of promoting social relationship satisfaction and positive attitudes towards old age in order to generate well-being, reduce levels of anxiety and prevent dissatisfaction due to fear to getting older

Single intracoronary injection of encapsulated antagomir-92a promotes angiogenesis and prevents adverse infarct remodeling.

BACKGROUND: Small and large preclinical animal models have shown that antagomir-92a-based therapy reduces early postischemic loss of function, but its effect on postinfarction remodeling is not known. In addition, the reported remote miR-92a inhibition in noncardiac organs prevents the translation of nonvectorized miR-targeted therapy to the clinical setting. We investigated whether a single intracoronary administration of antagomir-92a encapsulated in microspheres could prevent deleterious remodeling of myocardium 1 month after acute myocardial infarction AUTHOR: Should "acute" be added before "myocardial infarction" (since abbreviation is AMI)? Also check at first mention in main text (AMI) without adverse effects. METHODS AND RESULTS: In a percutaneous pig model of reperfused AMI, a single intracoronary administration of antagomir-92a encapsulated in specific microspheres (9 µm poly-d,-lactide-co-glycolide [PLGA]) inhibited miR-92a in a local, selective, and sustained manner (n=3 pigs euthanized 1, 3, and 10 days after treatment; 8×, 2×, and 5×-fold inhibition at 1, 3, and 10 days). Downregulation of miR-92a resulted in significant vessel growth (n=27 adult minipigs randomly allocated to blind receive encapsulated antagomir-92a, encapsulated placebo, or saline [n=8, 9, 9]; P=0.001), reduced regional wall-motion dysfunction (P=0.03), and prevented adverse remodeling in the infarct area 1 month after injury (P=0.03). Intracoronary injection of microspheres had no significant adverse effect in downstream myocardium in healthy pigs (n=2), and fluorescein isothiocyanate albumin-PLGA microspheres were not found in myocardium outside the left anterior descending coronary artery territory (n=4) or in other organs (n=2). CONCLUSIONS: Early single intracoronary administration of encapsulated antagomir-92a in an adult pig model of reperfused AMI prevents left ventricular remodeling with no local or distant adverse effects, emerging as a promising therapeutic approach to translate to patients who suffer a large AMI.

The respiratory syncytial virus G protein conserved domain induces a persistent and protective antibody response in rodents.

Respiratory syncytial virus (RSV) is an important cause of severe upper and lower respiratory disease in infants and in the elderly. There are 2 main RSV subtypes A and B. A recombinant vaccine was designed based on the central domain of the RSV-A attachment G protein which we had previously named G2Na (aa130-230). Here we evaluated immunogenicity, persistence of antibody (Ab) response and protective efficacy induced in rodents by: (i) G2Na fused to DT (Diphtheria toxin) fragments in cotton rats. DT fusion did not potentiate neutralizing Ab responses against RSV-A or cross-reactivity to RSV-B. (ii) G2Nb (aa130-230 of the RSV-B G protein) either fused to, or admixed with G2Na. G2Nb did not induce RSV-B-reactive Ab responses. (iii) G2Na at low doses. Two injections of 3 µg G2Na in Alum were sufficient to induce protective immune responses in mouse lungs, preventing RSV-A and greatly reducing RSV-B infections. In cotton rats, G2Na-induced RSV-reactive Ab and protective immunity against RSV-A challenge that persisted for at least 24 weeks. (iv) injecting RSV primed mice with a single dose of G2Na/Alum or G2Na/PLGA [poly(D,L-lactide-co-glycolide]. Despite the presence of pre-existing RSV-specific Abs, these formulations effectively boosted anti-RSV Ab titres and increased Ab titres persisted for at least 21 weeks. Affinity maturation of these Abs increased from day 28 to day 148. These data indicate that G2Na has potential as a component of an RSV vaccine formulation.