RESUMO
The use of modern chemotherapy (CT) allowed to achieve significant progress in the treatment of many malignant tumors that were previously considered fatal. Improving the efficiency of the treatment was achieved by the intensification of chemotherapy. However, intensification of chemotherapy regimes provoked increase in the number of side effects of anticancer therapy,which often lead to a decrease in the intensity of the selected mode, the additional financial costs of treating the complications and the formation of the negative attitude of the patient to treatment. Thus, the side effects of chemotherapy are the actual problem of modern oncology. The purpose of this literature review was to investigate the frequency, symptoms and ways to prevent and treat various types of toxicity of chemotherapy.
Assuntos
Antineoplásicos/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Náusea/tratamento farmacológico , Neutropenia/tratamento farmacológico , Substâncias Protetoras/uso terapêutico , Vômito/tratamento farmacológico , Antineoplásicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Feminino , Humanos , Náusea/induzido quimicamente , Náusea/diagnóstico , Náusea/metabolismo , Neutropenia/induzido quimicamente , Neutropenia/diagnóstico , Neutropenia/metabolismo , Receptores de Serotonina/metabolismo , Antagonistas da Serotonina/uso terapêutico , Vômito/induzido quimicamente , Vômito/diagnóstico , Vômito/metabolismoRESUMO
Treatment of patients with metastatic breast cancer is one of the most difficult problems of clinical oncology. Chemotherapy is one of the main methods of treatment of patients with metastatic breast cancer. Long experience of the world's cancer centers, advances in clinical oncology recent decades, the synthesis of anticancer drugs with new mechanisms of action have led to progress in the treatment of disseminated breast cancer. However, as shown by recent studies, the improvement of chemotherapy is not associated with reduced mortality from this disease. This paper presents the effectiveness of anticancer drugs and their combinations in the treatment of patients with metastatic breast cancer. Compliance with which, as it seems to us to produce superior results in treating this disease.
