RESUMO
The present study investigates anti-diabetic and anti-oxidant potentials of the aerial parts of Aerva javanica and seeds of Linum ustitatissimum. Our results revealed that maximum antioxidant activity was found in hexane fractions of both plants. Linum ustitatissimum recorded maximum antioxidant value of 15.77mmol/L while Aerva javanica had antioxidant activity of 16.07mmol/L. Anti-diabetic activities were also evaluated using normal rats, induced diabetic (untreated) rats and treated diabetic rats. Aerva javanica revealed a significant potential in decreasing blood glucose level to 77.08mg/dl and body weight 76.30mg/kg while Linum ustitatissimum reduced blood glucose level to 84.20mg/dl and body weight 83.090mg/kg. From these results it can be concluded that both plants possesses anti-diabetic and anti-oxidant activity.
Assuntos
Amaranthaceae/química , Antioxidantes/farmacologia , Glicemia/efeitos dos fármacos , Diabetes Mellitus Experimental/tratamento farmacológico , Linho/química , Hipoglicemiantes/farmacologia , Extratos Vegetais/farmacologia , Aloxano , Animais , Antioxidantes/química , Antioxidantes/isolamento & purificação , Benzotiazóis/química , Biomarcadores/sangue , Compostos de Bifenilo/química , Glicemia/metabolismo , Cloretos/química , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/induzido quimicamente , Compostos Férricos/química , Hexanos/química , Hipoglicemiantes/química , Hipoglicemiantes/isolamento & purificação , Oxirredução , Fitoterapia , Picratos/química , Componentes Aéreos da Planta/química , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Ratos , Solventes/química , Ácidos Sulfônicos/químicaRESUMO
The present study reveals antimicrobial potentials and phytochemical analysis of A. javanica and L. ustitatissimum. Phytochemical analysis indicated that the tested plants contained a substantial amount of flavonoids, terpenoids and steroids while saponins and tannins were absent in L. ustitatissimum, however, tannins were present in A. javanica. L. ustitatissimum contained maximum total phenolic content of 166.36mg/g in methylated spirit fraction while its ethyl acetate fraction contained highest quantity of flavonoids 27.6mg/g in case of Aerva javanica. Antimicrobial potentials of the subject plants revealed that L. ustitatissimum had maximum antibacterial activity (MIC=4.33µg/ml) while A. javanica was most effective against fungal strains (MIC=2.66µg/ml).