Panorama des dermatoses tumorales vues en consultation dermatologique au Centre National Hospitalier Universitaire Hubert Koutoukou Maga de Cotonou au Bénin / Overview of tumoral dermatoses seen in dermatological consultation at the National University Hospital Center Hubert Koutoukou Maga in Cotonou, Benin

Introduction Les dermatoses tumorales sont des néoformations tissulaires dues à une prolifération cellulaire excessive, anormale, anarchique et plus ou moins autonome, aux dépens de la peau et de ses annexes. Ces dermatoses tumorales peuvent être bénignes, malignes ou à malignité limitée. L'objectif de la présente étude est de répertorier l'ensemble des dermatoses tumorales vues en consultation dermatologique au CNHU-HKM de Cotonou. Patients et méthodes Etude transversale rétrospective et descriptive ayant porté sur les dossiers des patients vus pour des tumeurs cutanéo-muqueuses, dans le service de Dermatologie-vénérologie du Centre National Hospitalier Universitaire Hubert Koutoukou Maga (CNHU-HKM) de Cotonou, de 2009 à 2023. Les données épidémiologiques et cliniques ont été recueillies à partir des registres de consultations puis saisies et analysées avec les logiciels Excel, EPI-DATA et SPSS. Résultats Au total, 15627 nouveaux patients ont été enregistrés, dont 1221 atteints de dermatoses tumorales (7,81%). L'âge moyen était de 33 ans ± 18,71 ; la tranche d'âge la plus représentée était celle de 20 à 39 ans (46,30%). La sex-ratio était de 1,08. Les lésions étaient acquises chez 93,94% des patients. Trente-cinq types de dermatoses tumorales ont été colligés. Les tumeurs bénignes représentaient 95,43% des patients. Elles étaient dominées par les chéloïdes (25,34 %) suivies parles condylomes (17,50 %), les verrues (10,12%), le molluscum contagiosum (7,54 %), l'ensemble formé par les nævi et hamartomes (5,18 %) et les kystes sébacés (4,57 %). Les tumeurs malignes étaient rares et représentées par les carcinomes spinocellulaires (1,14%), basocellulaires (0,30%) et les mélanomes (0,30%). Les tumeurs à malignité limitée sont essentiellement représentées par la maladie de Kaposi retrouvée chez 2,05% des patients. Conclusion Les dermatoses tumorales sont relativement fréquentes en milieu hospitalier au Bénin. Elles sont dominées par les tumeurs bénignes avec à leur tête les chéloïdes et les condylomes

Introduction Tumoral dermatoses are tissue neoformations resulting from excessive, abnormal, anarchic, and somewhat autonomous cell proliferation, affecting the skin and its annexes. These tumoral dermatoses can be benign, malignant, or of limited malignancy. The aim of this study is to catalog all the tumoral dermatoses seen in dermatological consultation at NUHC- HKM in Cotonou. Patients and Methods This was a retrospective, descriptive cross-sectional study based on the files of patients seen for cutaneous or mucosal tumors in the Dermatology-Venereology department of the National University Hospital Center Hubert Koutoukou Maga (NUHC-HKM) in Cotonou, from 2009 to 2023. Epidemiological and clinical data were collected from consultation registers and analyzed using Excel, EPI-DATA, and SPSS software. A total of 15,627 new patients were registered, of which 1,221 were affected by tumoral dermatoses (7.81%). The average age was 33 years ± 18.71; the most represented age group was 20 to 39 years (46.30%). The sex ratio was 1.08. Thirty-five types of tumoral dermatoses were collected. The lesions were non congenital in 93.94% of patients. Benign tumors accounted for 95.43% of the patients. They were dominated by keloids (25.34%) followed by condylomas (17.50%), warts (10.12%), molluscum contagiosum (7.54%), the group formed by nevi and hamartomas (5.18%), and sebaceous cysts (4.57%). Malignant tumors were rare and represented by squamous cell carcinomas (1.14%), basal cell carcinomas (0.30%), and melanomas (0.30%). Tumors with limited malignancy were primarily represented by Kaposi's disease found in 2.05% of patients. Conclusion Tumoral dermatoses are relatively frequent in the hospital setting in Benin. They are dominated by benign tumors, headed by keloids and condylomas

Anemia in the period immediately following renal transplantation.

INTRODUCTION: Anemia remains frequent in the first month following renal transplantation and is a risk factor for cardiovascular accidents. The purpose of this study was to analyze the prevalence of anemia during this period notably among different immunosuppressive treatment groups. METHODS: In this study, we entered the patients who had received a renal allograft in our transplant unit from 1993 to 2003, including patients who had received azathioprine (AZA) from 1993 to 1996 and mycophenolate mofetil (MMF) from 1996 to 2003. No patient received rHu-erythropoietin after transplantation during that period. A mathematical model normalized the hemoglobin (Hb) threshold level at which blood transfusion was decided and Hb on admission. RESULTS: One hundred and eighty-eight patients on AZA and 223 on MMF were included in the analysis. The mean age +/- SD was 41 +/- 12 years in the AZA group, and 45 +/- 12 years in the MMF group (P < .006). Before the transplantation, Hb was higher in the MMF group (11.4 +/- 1.9 vs 10.2 +/- 2 g/dL, P < .0001). After normalization at a threshold level of transfusion of 7 g/dL, transfusions were more frequent among the MMF group (72% vs 48%, P < .0001). Double therapy with MMF (1500 mg/d) + steroids or therapy with MMF (750 mg/d) + tacrolimus + steroids increased the risk of transfusion compared to the AZA group. MMF (750 mg/d) + cyclosporine conferred a similar risk of transfusion compared with the AZA group. CONCLUSION: MMF alone or in association with tacrolimus is associated with an increased risk of anemia and transfusion in the immediate posttransplantation period.