[Bacteriological monitoring of infective agents of purulent septic diseases in an emergency hospital]. / Monitoring vozbuditelei gnoino-septicheskikh zabolevanii v statsionare skoroi meditsinskoi pomoshchi.

During the period of 1995-2001 bacteriological examination of 13,842 patients with purulent septic diseases (PSD) was carried out. The statistical processing of data revealed that equalization of the dynamic rows of intensive and extensive values characterizing the number of patients with PSD caused by etiologically important infective agents made it possible to evaluate the reliability of information. A trend to increased etiological importance of the genera Pseudomonas, Escherichia and Klebsiella was established. The number of diseases caused by Staphylococcus, Streptococcus, Enterococcus and Proteus decreased.

[Antibiotic susceptibility of the bacterial strains isolated at the emergency hospital]. / Lekarstvennaia chuvstvitel'nost' vozbuditelei gnoino-septicheskikh protsesov v statsionare skoroi pomoshchi.

Comparative evaluation of the incidence of the drug resistant pathogens at the patients with sepsis was performed. High ratio of the resistnt strain was shown and the most potent drugs were estimated. The investigation results demonstrates the necessity to improve diagnostic quality control. The data on drug susceptibility of the pathogens may be used for their taxonomic clarification.

[Dynamics of antibiotic resistance of purulent septic pathogens at an emergency facility]. / Dinamika antibiotikorezistentnosti vozbuditelei gnoino-septicheskikh protsessov v statsionare skoroi pomoshchi.

The predominant pathogens at the emergency medicine hospital were analysed and its resistance to antibiotics was investigated in dynamics. The susceptibility of the pathogens was analysed by the method of dynamic equalibration. Statistically significant reduction of resistant bacteria isolation was demonstrated for 2 species of 7--that is S. aureus and E. faecalis regarding 4 antibiotics. The ratio of staphylococci resistant to cefazolin, ceftazidime, doxycyclin reduced, the ratio of enterococci resistant to chloramphenicol and doxycyclin also diminished. No correlation was demonstrated between the pathogen isolation frequency and ratio of resistant strains.

[Comparative population study of the etiological role of causative agents of purulent inflammatory diseases and serum antibodies to antigens of opportunistic microorganisms]. / Sravnitel'noe populiatsionnoe izuchenie étiologicheskoi znachimosti vozbuditelei gnoino-vospalitel'nykh zabolevanii i syvorotochnykh antitel k antigenam uslovnopatogennykh mikroorganizmov.

The comparative study of the relationship between the levels of serum antibodies to the antigens of opportunistic microorganisms of 5 genera (Pseudomonas, Proteus, Staphylococcus, Klebsiella, Escherichia) and the microbial status was carried out. A total of 854 patients from 10 profile departments of a surgical hospital were examined. Population analysis and statistical methods of processing the results of the examination of 353 practically healthy subjects and 268 blood and plasma donors permitted the norms for the levels of specific antimicrobial antibodies (decreased, normal, elevated levels) were established. The constancy coefficients of Pseudomonas, Staphylococcus, Klebsiella, Escherichia and the number of patients with elevated titers of specific serum antibodies were found to be positively correlated (r = +0.47-0.89, p < 0.01). The data thus obtained made it possible to substantiate the importance of population serological investigations for the evaluation of the epidemiological situation in the surgical hospital.

[The use of data on the composition and drug resistance of the causative agents of suppuration in a retrospective analysis of the epidemiological situation in a hospital]. / Ispol'zovanie dannykh o sostave i lekarstvennoi ustoichivosti vozbuditelei nagnoenii pri retrospektivnom analize épidemiologicheskoi situatsii v statsionare.

The analysis of bacterial 16,530 strains, dynamically isolated from 6,157 patients with purulent septic processes (PSP) in surgical, traumatological, burn, toxicological and resuscitation departments, was made. The computer processing of data on the spread of the causative agents of PSP, depending on their taxonomic classification and drug resistance spectra, was carried out, which made in possible to obtain information on the outbreaks of hospital infections. Correlation of the number of PSP cases and the spread of hospital resistovars was analyzed. The data on the composition and drug resistance of pyogenic microorganisms could be used in the retrospective analysis of the epidemiological situation in a hospital. 3-year observations revealed the tendency to a decrease in the spread of the hospital variants of the causative agents of PSP, multiresistant to antibacterial preparations, which was indicative of the effectiveness of the antiepidemic measures carried out during this period.

[Tasks and possibilities of bacteriological laboratories in computer-assisted control of hospital infections]. / Zadachi i vozmozhnosti bakteriologicheskikh laboratorii pri komp'iuternom kontrole vnutribol'nichnykh infektsii.

The authors discuss the organization of epidemiological surveillance of hospital infections, carried out by bacteriological laboratories. The principal tasks of epidemiological surveillance of pyoseptic infections in surgical hospitals are formulated. The potentialities of using the data of computer monitoring of nosocomial infections are discussed. This method helps adopt epidemiologically justified decisions.