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Int J Radiat Biol ; 95(12): 1659-1667, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31490087

RESUMO

Purpose: This paper describes how the BioDoseNet image repository was used as a training tool for the dicentric assay.Materials and methods: The training was implemented in three phases: introduction to dicentric scoring, dose response curve elaboration and dose assessment exercise. Four labs without previous experience in the dicentric assay participated and four modules of the repository were used.Results: The labs become familiar with aberrations induced by ionizing radiation. The labs were able to generate data for the elaboration of a dose response curve and then successfully estimated doses and irradiated fractions in six blind samples.Conclusions: The performance of these laboratories during the exercise demonstrates the efficacy of the BioDoseNet image repository as a training tool and the utility of web based scoring for the dicentric assay community.


Assuntos
Aberrações Cromossômicas/efeitos da radiação , Análise Citogenética , Bases de Dados Factuais , Imagem Molecular , Calibragem , Relação Dose-Resposta à Radiação , Metáfase/genética , Metáfase/efeitos da radiação
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