RESUMO
Background & aims: Vitamin D supplementation as animmunomodulator has been identified as a potential strategy to prevent and treat Coronavirus disease 2019 (COVID-19). We aimed to analyze the effect of 10,000 IU vitamin D3supplementation on 25(OH)D levels on primary clinical outcomes (conversion length), inflammatory markers (TotalLymphocyte Count (TLC), Neutrophil-to-Lymphocyte Ratio(NLR), Platelet-to-Lymphocyte Ratio (PLR)) and coagulationmarker (D-Dimer) in moderate COVID-19 patients atWahidin Sudirohusodo Hospital, Makassar, Indonesia.Methods: We conducted a singleblind randomized-controlled trial on the confirmed moderate COVID-19 patientsabove 18 years old and low vitamin D status. Each of inter-vention and control groups were supplemented of 10,000 IUand 1000 IU cholecalciferol that taken daily for 2 weeks.Levels of 25(OH)D were analyzed for the primary endpoint(conversion length), then correlated to secondary endpoints(Length of Stay (LOS)), clinical manifestations improvement,and markers TLC, NLR, PLR, and D-Dimer serum, handgripstrength (HGS) as functional capacity measurement, after ad-justed to age, sex, nutritional status based on body mass in-dex (BMI) and Subjective Global Assessment (SGA) tool, co-morbidities, and anticoagulant administration. Medical nutri-tional therapy was given and presented as energy, protein,carbohydrate, and fat achievement, and vitamin D intake wasalso calculated.Results: A significant effects was found in 60 samples withpre-intervention vitamin D deficiency (61.7%) and insuffi-ciency (38.3%) status, and 10,000 IU of vitamin D3 supplementation could increase 25(OH)D levels within 2 weeks toreach sufficiency status (16.7%). The Vitamin D3 supplementation of 10,000 IU and 1000 IU could significantly increase25(OH)D levels compared to the control group of 1000 IU(4.61±5.43 vs. -0.29±2.72; P <0.0001) and it was correlatedto primary clinical outcome, which is length of conversion...(AU)
Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Pandemias , Infecções por Coronavirus/epidemiologia , Transtornos da Coagulação Sanguínea , Vitamina D , Estado Nutricional , Índice de Massa Corporal , Indonésia , 52503RESUMO
Backgrounds and aim: Dietary patterns play an important role in the emergence of non-communicable diseases such as obesity, hypertension, and metabolic syndrome. This study aims to examine the impact of ultra-processed food on the nutritional status and body composition of modern and traditional population groups in Indonesia. Methods: The study has received ethical approval from the Research Ethics Commission of the Faculty of Medicine, Hasanuddin University with ethics number No.633/UN4.6.4.5.31/PP36/2022. The inclusion criteria in this study included: people in the Makassar population > 50 years old. Exclusion criteria were (1) having chronic gastrointestinal disease/chronic inflammation, (2) having Diabetes Mellitus, (3) consuming antibiotics in the last 3 months, (4) consuming prebiotics/probiotics, (5) having income > IDR 3,400.000,-, (6) rarely (<1x/week) consumes UPF.About 100 samples were taken from people over 50 years old, where 50 samples were taken from both the modern group and the traditional group. To evaluate the dietary pattern, the diet of the sampling persons was analyzed by using a semi-quantitative Food Frequency Questionnaire (SQ-FFQ), and a 24-hours food recall (FR) to examine the food intake. Body Mass Index (BMI) and Waist Circumference (WC) were used to determine the nutritional status, while the body composition was assessed by Tanita BC 730. Results: According to the scatter plot, the higher the ultra-processed food energy consumed, the higher the BMI, Waist Circumference, and Fat Mass results, with the respective effects of 18.4%, 35.3%, and 13.7%. From this study, it was found that there were significant differences (p<0.05) between the traditional and modern groups in all variables except for height based on the independent t-test found no significant difference (p>0.05). Conclusions: In conclusion, dietary patterns with higher consumption of ultra-processed foods influence the increase of body mass index, waist circumference...(AU)
