Transverse tomosynthesis on a digital simulator.

The availability of digital radiographic imaging on simulators has led to the investigation of a number of new imaging possibilities, including digital linear tomography (tomosynthesis). It has been shown that a single set of projections in this case is sufficient to reconstruct images from multiple planes, including planes tilted with respect to the tube motion. The present work examines the feasibility of tomosynthetic image reconstruction in transverse planes using a CCD-based digital radiotherapy simulator with conventional isocentric rotational geometry. General transformation equations were derived to permit image reconstruction in arbitrary transverse planes. Transverse images of the skull section of the humanoid phantom have been generated using a 360 degrees gantry sweep. Bone, air, and radiographic markers are well resolved, but the image quality is poor due to the suboptimal scanning geometry available on the simulator.

Clinical use of a digital simulator for rapid setup verification in high dose rate brachytherapy.

PURPOSE: Fractionated high dose rate (HDR) brachytherapy provides a number of technical advantages over conventional implant therapy in that (a) it can be carried out on an outpatient basis, (b) personnel exposure is reduced to insignificant levels, and (c) patient motion during irradiation is minimized, resulting in a more accurate delivery of the planned radiation dose distribution to the target and critical structures. The patient discomfort associated with the repeated applicator insertions and/or treatment setups can be alleviated to the extent that the setup time is held to a minimum. This work describes the use of a prototype digital simulator to obtain fast, high-quality digital images for rapid setup verification. METHODS AND MATERIALS: The digital imaging system of the prototype simulator consists of a charge-coupled device (CCD) camera, which views the x-ray image optically transmitted from a conventional phosphor screen. Treatment is carried out with a remote afterloading HDR unit immediately after setup verification with the patient on the simulator stretcher. The high-resolution digital images are processed and displayed in about 5 s, as opposed to a minimum of approximately 2 min for film. RESULTS: The imaging system has been evaluated for a variety of implant types, both intracavitary and interstitial. The digital radiographs provided permanent high-resolution images as required in most cases for precise applicator positioning. The gray scale manipulation capabilities were found to be useful for imaging in regions of different density, such as lung and soft tissue, in the same radiograph. The advantages of short image acquisition and display times were observed in all cases, but were most evident in the intraluminal procedures, which sometimes involved several pretreatment applicator adjustments at a time of considerable patient discomfort. CONCLUSION: Pretreatment imaging is necessary to fully exploit the technical advantages of HDR brachytherapy. High-quality digital radiography offers unique advantages in HDR setup and verification by providing fast high-resolution, undistorted images with software manipulation capabilities and permanent storage of images.

Performance evaluation of a prototype high resolution digital radiographic/near real-time fluoroscopic computerized tomographic system for radiotherapy simulation.

PURPOSE: A new prototype digital radiographic/near real-time fluoroscopic and computerized tomographic (CT) imaging system has been developed and its performance is evaluated for future implementation in a radiotherapy simulator. METHODS AND MATERIALS: The new imaging modality uses a slow scan cooled charge-coupled device (CCD) camera with 2 k x 2 k x 12 bit image resolution. X-ray images formed by a Gd2O2S:Tb flat screen are directly viewed by the CCD camera via a 45 degrees angled mirror and a high speed objective lens. For CT image reconstruction, digital data from a slit image on the CCD array obtained from time-controlled x-ray scans around the object are transferred to a second tomographic computer for processing and display. RESULTS: In the digital radiographic mode, and for a 43.2 x 43.2 cm field size at the phosphor plane, the spatial resolution of the system is 2.3 +/- 0.1 lp/mm (1 sigma) as measured at the 4% level of the modulation transfer function (MTF), whereas the contrast resolution has a value of 0.5%. In the fluoroscopic mode, the system may be operated at a maximum rate of eight frames/s at a relatively lower spatial and contrast resolution. For CT scans, although the potential intrinsic spatial resolution at the isocenter is 0.35 mm, display-limited spatial resolutions of 1.2 and 1.6 mm were obtained for 30 and 40 cm reconstruction circle diameters, respectively. A contrast resolution of 1% at 0.015 Gy entrance dose was achieved, and CT reconstruction circles of up to 51 cm were attainable. CONCLUSION: The new CCD-based imaging system is capable of delivering high-quality digital radiographic and CT images for radiotherapy simulation, whereas the near real-time fluoroscopic mode yields acceptable flicker-free lower quality images at object speeds typical of simulation motions.

Performance characteristics of a real-time digital x-ray fluoroscopic system using an intensified charge injection device camera and CsI:Na crystal.

A digital x-ray photoelectronic imaging system has been constructed using an optically flat 152-mm-diam, 2.5-mm-thick CsI:Na scintillating crystal. X-ray images formed by the scintillator are viewed by a single microchannel plate intensified charge injection device (ICID) camera and digitized at a real-time rate by a computerized frame-grabbing system. Video images are recorded and selected image frames are subjected to image processing and analysis schemes. Parameters governing the performance characteristics of the system are determined accordingly. For a 152-mm field size at the crystal plane, a spatial resolution limit of 1.50 +/- 0.10 1p/mm (1 sigma) measured at the 4% level of the modulation transfer function of the system has been obtained. This result is consistent with the measurements of the full width at half-maximum of the line spread function which is found to be 645 +/- 35 microns (1 sigma). Similarly, the intrinsic resolution of the CsI:Na scintillator only was found to be 6.5 +/- 0.5 1p/mm (1 sigma). Contrast ratio measurements, which are mainly determined by the quality of phosphor, have indicated a value of 12.1 +/- 0.6, whereas minimum visible details are observed at radiation exposure rates of 100 microR/s. This limit has been reduced to 10 microR/s using the single-scan integrating option provided by the ICID camera. A maximum contrast resolution of 1% corresponding to 100 statistically significant meaningful gray levels is achieved at a maximum exposure rate of 1000 microR/s. Consequently, although the imaging capability of the present system compares favorably with that of conventional x-ray video-fluoroscopic systems, a better performance may be achieved by using a higher resolution cooled dual-microchannel intensified CID camera in conjunction with a thinner CsI:Na crystal and a real-time digital image processing subsystem.

A high-resolution digital dosimetric system for spatial characterization of radiation fields using a thermoluminescent CaF2:Dy crystal.

A high-resolution digital dosimetric system has been developed for the spatial characterization of radiation fields. The system comprises the following: 0.5-mm-thick, 25-mm-diam CaF2:Dy thermoluminescent crystal; intensified charge coupled device video camera; video cassette recorder; and a computerized image processing subsystem. The optically flat single crystal is used as a radiation imaging device and the subsequent thermally stimulated phosphorescence is viewed by the intensified camera for further processing and analysis. Parameters governing the performance characteristics of the system were measured. A spatial resolution limit of 31 +/- 2 microns (1 sigma) corresponding to 16 +/- 1 line pairs/mm measured at the 4% level of the modulation transfer function has been achieved. The full width at half maximum of the line spread function measured independently by the slit method or derived from the edge response function was found to be 69 +/- 4 microns (1 sigma). The high resolving power, speed of readout, good precision, wide dynamic range, and the large image storage capacity make the system suitable for the digital mapping of the relative distribution of absorbed doses for various small radiation fields and the edges of larger fields.

Lyoluminescence response of irradiated saccharides to radiation quality effects.

Lyoluminescence sensitivity of five different saccharide powders to electron irradiation has been determined using luminol solution as a solvent. Effect of electron energy variation in the range of 5-20 MeV on the lyoluminescence yield has been measured. The light conversion efficiencies of different saccharides irradiated with x-rays, beta-particles, gamma-rays, fast electrons, 170-MeV/c pi(-)-mesons and 8-MeV neutrons have been calculated. Factors affecting light conversion efficiency, sensitivity and accuracy of measurements are discussed.

A lyoluminescent tissue-equivalent dosemeter for pion therapy beams.

The light emitted when pion irradiated glucose is dissolved in luminol solution has been found to be proportional to the pion beam depth dose distribution in water as determined by a TE ionisation chamber. The lyoluminescence of glucose overlaps very closely with the response profile of the ionisation chamber to the 170 MeV/c pi--mesons giving a Bragg peak to plateau ratio of 3:1. In comparison, the thermoluminescence response of LiF (TLD-700) to pions has been found to deviate significantly from this ratio. The close tissue equivalence of glucose, non-toxicity and its excellent lyoluminescent retention properties are important advantages over currently used dosemeters in clinical pion therapy, especially when direct in vivo measurements are considered. Pion doses ranging between 0.5 Gy (50 rad) and 30 Gy (3000 rad) were measured with an accuracy +/- 5% and reproducibility 3-5%.