Obstetric outcomes of Human Immunodeficiency Virus positive mothers in tertiary care hospital.

OBJECTIVE: To evaluate the pregnancy outcome of human immunodeficiency syndrome-positive mothers. METHODS: The prospective observational study was conducted at the Department of Gynaecology and Obstetrics, Aziz Bhatti Shaheed Teaching Hospital, Gujrat, Pakistan, from June 2011 to March 2018, and comprised pregnant women screened positive for human immunodeficiency syndrome. Risk factors and perinatal outcomes were noted on a predesigned proforma. Data was analysed using SPSS 20. RESULTS: Of the 74 subjects with a mean age of 29±5.27 years, 63(85.1%) were multiparous and 11(14.9%) were nulliparous. Major risk factors included unsterilized nasal or ear piercing in 70(94.6%) subjects, history of blood transfusion 57(77%) and history of dental procedure in unsterilized settings 23(31.1%). Spouses of 43(58.1%) subjects were positive for human immunodeficiency syndrome, 22(29.7%) were negative and 9(12.2%) had unknown status in this regard. In terms of outcome, 12(16.3%) subjects had spontaneous abortion, 11(12.2%) had intrauterine death of foetus, 6(8.1%) had preterm delivery and 45(60.8%) reached full term and were delivered. There were 2(2.6%) patients with stage 4 disease who died during pregnancy. CONCLUSIONS: Human immunodeficiency syndrome infection in pregnant women was found to be associated with poor pregnancy outcome.

Frequency of different types of gastric varices in patients with cirrhosis due to chronic hepatitis C.

OBJECTIVE: To determine the frequency of different types of gastric varices in patients with hepatitis C virus-related cirrhosis. METHODS: The observational cross-sectional study was conducted from August 2014 to August 2015 at Aziz Bhatti Shaheed Teaching Hospital, Gujrat, Pakistan, using non-probability consecutive sampling. Patients having liver cirrhosis only due to chronic hepatitis C virus, portal vein diameter >12mm or spleen size >12cm in long axis and ascites with no previous history of variceal banding were included. Patients having cirrhosis due to other causes were excluded. Data was collected using a proforma that was filled by taking history, laboratory studies, abdominal ultrasound and upper gastrointestinal endoscopy. Gastric varices were classified using Sarin classification. SPSS 20 was used for statistical analysis. RESULTS: Out of 205 patients undergoing esophago-gastroduodenoscopy, 122(59.5%) were male and 83(40.5%) were female with an overall mean age of 49.5±7.49 years. Gastric varices were present in 30(14.6%) patients. Among them, type 1 was present in 23(76.71%), type 2 in 6(19.86%) and isolated gastric varices type 1 in 3(10.27%).Isolated gastric varices type 2 was not present in any patient. CONCLUSIONS: Gastric varices were present in minority of patients undergoing esophago-gastroduodenoscopy, and among them, gastroesophageal varices type 1 was the most common, while isolated gastric varices type 2 was not present in any patient.