RESUMO
Two organotin compounds, tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), that have antifungal potentials and are intended for use on yam root crops to prevent rot were evaluated for acute mammalian toxicity in rats. The median lethal doses po were 297.54 mg TBTA/kg and 402.38 mg TPTA/kg. Both compounds produced significant central nervous system and respiratory depressions at single doses of 200 mg TBTA/kg or 300 mg TPTA/kg. The histopathological findings due to TBTA included pulmonary, hepatic and renal congestion, brain hemorrhages, and destruction of the intestinal mucosa. TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.
Assuntos
Fungicidas Industriais/toxicidade , Compostos Orgânicos de Estanho/toxicidade , Compostos de Trialquitina/toxicidade , Animais , Relação Dose-Resposta a Droga , Feminino , Fungicidas Industriais/administração & dosagem , Gastroenteropatias/induzido quimicamente , Gastroenteropatias/patologia , Dose Letal Mediana , Masculino , Compostos Orgânicos de Estanho/administração & dosagem , Ratos , Dermatopatias/induzido quimicamente , Dermatopatias/patologia , Compostos de Trialquitina/administração & dosagemRESUMO
The effects of a moderate but prolonged exposure of rats to tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), as might be encountered as residues in yam peel diets, were investigated in rats. These subchronic toxicity studies (16, 8, or 4 mg TBTA/kg and 20, 10 or 5 mg TPTA/kg) showed histopathologic lesions in lungs, liver, intestine and kidney. The hematologic parameters in the groups treated with either compound fell within the normal range for the rats. However, there was a reduction in mean lymphocyte count for rats receiving 10 or 20 mg TPTA/kg, and a reduction in monocyte count in the 20 mg TPTA/kg group. These data indicate a need for further toxicologic studies and cautionary measures to avoid ingestion, inhalation or contamination of dietary materials by these fungicides.
