Arterial access site closure with a novel sealing device: Duett.

Management of arterial access sites following percutaneous endovascular procedures is associated with patient discomfort and local complications. A new vascular sealing device, comprised of a balloon delivery catheter and a flowable procoagulant consisting of thrombin and collagen, was tested. Immediately following catheterization 200 patients (age, 66.1 +/- 11.2 years) were treated with the sealing device (Duett). Of these 200 patients, 132 underwent diagnostic catheterization, 67 underwent percutaneous transluminal coronary angioplasty, and one underwent percutaneous transluminal angioplasty. The sheath sizes included 2-5 Fr, 166-6 Fr, 25-7 Fr and 7-8 Fr. All patients undergoing diagnostic procedures received at least 5,000 U of intravenous heparin during the procedure. The Duett was used successfully in 198/200 (99%) patients immediately following completion of the endovascular procedure. In two patients a device malfunction resulted in uncomplicated crossover to manual compression. The time to hemostasis ranged from 3 to 5 minutes. All patients were walking 2 to 5 hours following the procedure unless a complication had occurred. No patient experienced leg ischemia, required surgical repair of the arterial access site, or had an infection at the site. In three patients (1.5%), a pseudoaneurysm occurred and was successfully treated with ultrasound-guided compression and three patients received a blood transfusion. No late complications were observed following hospital discharge. This novel vascular sealing device successfully achieves rapid hemostasis and allows early ambulation following percutaneous endovascular procedures with a low incidence of complications.

Risk prediction in operatively treated fractures of the hip.

There have appeared no objective means by which preoperative risk in patients with fractures of the hip can be quantitatively predicted. The developed risk's core is based on medical history, physical examination, chest radiograph, and screening laboratory data. This system reproducibly assigns patients into one of three groups. Three hundred seventeen patients with surgically treated hip fractures (93 femoral head, 166 neck, 58 intertrochanteric fractures) were analyzed in this study. Surgical treatment included 102 Ender-pinnings, 43 Böhler-nails, 79 dynamic hip screws, and 93 endoprostheses of the hip (according to fracture type). Overall mortality rate during hospitalization was 9.5%. The mortality rate in Group I was 2.5%; in Group II, 11.9%; and in Group III, 44.1%. The medical complications in Group I were 12.6%; in Group II, 28.6%; and in Group III, 67.6%. The difference for each group was significant. This preoperative risk assessment appears effective in more accurately identifying patient risk.