RESUMO
BACKGROUND: Few articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in postbariatric patients. The purpose of this study was to explore bile acid, glucose, lipid, and liver enzyme changes in patients with different diabetes statuses who underwent sleeve gastrectomy. The impact of bariatric surgery and its potential benefits for prediabetic patients was also discussed. METHODS: A total of 202 overweight and obese patients who underwent bariatric surgery in our hospital between January 2016 and October 2018 were retrospectively reviewed. Patients were divided into prediabetes (n = 32), nondiabetes (n = 144), and diabetes (n = 26) groups and analysed. Glucose and lipid data were collected from medical records at baseline and at each follow-up visit. RESULT: Significant improvements in body weight, glucose and lipid levels, and liver enzymes (P ≤ 0.05) in prediabetic patients were found throughout the first year postoperatively. Improvement in glycaemic control was first seen one month postoperatively, followed by persistent improvement in the next 12 months. Total bile acid (TBA) decreased, which was associated with ALT improvement in prediabetic patients 1-year post-surgery. There were no significant differences in HbA1c, glucose, or triglycerides (TGs) between prediabetic and T2DM patients or between prediabetic and nondiabetic patients at 12 months post-surgery. CONCLUSION: LSG is highly effective at interfering with glucose and lipid levels as well as total bile acid levels in prediabetic patients in the first year postoperatively. Thus, LSG is indeed an alternative for overweight and obese prediabetic patients.
Assuntos
Ácidos e Sais Biliares , Glicemia , Diabetes Mellitus Tipo 2/cirurgia , Gastrectomia/efeitos adversos , Obesidade Mórbida/cirurgia , Estado Pré-Diabético/cirurgia , Adulto , Diabetes Mellitus Tipo 2/sangue , Feminino , Humanos , Laparoscopia , Metabolismo dos Lipídeos , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Estado Pré-Diabético/sangue , Estudos Retrospectivos , Resultado do TratamentoRESUMO
A single-measurement sweep-free distributed Brillouin optical time domain analyzer (BOTDA) sensor based on phase detection is proposed and experimentally demonstrated employing digital optical frequency comb (DOFC) probe signal. Brillouin Phase Spectrum (BPS) of DOFC probe induced by Brillouin interaction is measured using coherent detection in a single acquisition, without any frequency scanning and data averaging. Single-measurement BOTDA sensor based on BPS in 10km long fiber is demonstrated with a response time of 100 µs, which is limited only by the fiber length. The spatial resolution is 51.2m, determined by the duration of DOFC. And the Brillouin frequency shift (BFS) uncertainty is estimated to be~1.5 MHz at the end of fiber under test (FUT). Benefiting from the fast response time, dynamic measurement up to 1 kHz vibration frequency has been demonstrated.
