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2.
Clin. transl. oncol. (Print) ; 10(10): 604-617, oct. 2008. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-123529

RESUMO

Worldwide, cervical and uterine cancers are the most deadly cancers in women, with high prevalences, especially in developing countries. The Human Protein Atlas (HPA) portal was explored for proteins expressed in a tissue- or cervix and uterine cancer-specific manner. The group of proteins differentially expressed and with enhanced expression in the glandular and surface epithelial (squamous) cells retrieved from HPA were further explored using the Protein Information and Knowledge Extractor (PIKE) portal to compile biological information that is found in different databases, and repositories on the Internet. Thus, the lists of candidate proteins found in HPA, and PIKE portals may be used as a starting point for the discovery and validation of biomarkers for cervix and uterine cancer employing proteomics approaches as described in the present article (AU)


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Assuntos
Humanos , Feminino , Biologia Computacional , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/metabolismo , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/metabolismo , Bases de Dados de Proteínas , Neoplasias do Endométrio/metabolismo , Modelos Biológicos , Proteômica/métodos , Software/tendências
5.
Med Clin (Barc) ; 95(14): 521-4, 1990 Oct 27.
Artigo em Espanhol | MEDLINE | ID: mdl-1964708

RESUMO

The possible myocardial injury induced by electrical cardioversion in the treatment of supraventricular arrhythmias was analyzed after 45 countershocks of 200 joules and after 6 of 600 joules (total accumulated energy). In all patients myocardial injury was evaluated by serial CK, CK-Mb, and myoglobin determinations and in 48 cases a cardiac gammagraphy with technetium pyrophosphate was also performed. Significant increases in total CK and myoglobin were observed in 2 (4%) patients treated with 200 joules and in 3 (50%) patients receiving 600 joules. CK-Mb was also increased in one patient receiving 200 joules (13.5 U/I) and in one patient treated with 600 joules (27.8 U/I). In all cases technetium gammagraphy was negative.


Assuntos
Cardiomiopatias/etiologia , Cardioversão Elétrica/efeitos adversos , Adulto , Arritmias Cardíacas/complicações , Arritmias Cardíacas/terapia , Cardiomiopatias/diagnóstico , Ensaios Enzimáticos Clínicos , Creatina Quinase/sangue , Difosfatos , Cardioversão Elétrica/métodos , Feminino , Coração/diagnóstico por imagem , Humanos , Isoenzimas , Masculino , Pessoa de Meia-Idade , Mioglobina/sangue , Cintilografia , Tecnécio , Pirofosfato de Tecnécio Tc 99m , Fatores de Tempo
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