[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats]. / Action tératogène d'un inhibiteur de la synthèse du cholestérol chez les rats Wistar et Sprague-Dawley.

Sprague-Dawley rats are sensitive to the teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, but the dose of inhibitor necessary to induce the same rate of characteristic malformations is twice as large for Sprague-Dawley as for Wistar rats. This variation is probably related to differences in levels of blood cholesterol in the strains and demonstrates a relationship between teratogenicity and metabolic disturbances.

[Incorporation of 3H-thymidine in Wistar rat embryos treated with AY 9944]. / Incorporation de 3H-thymidine chez les embryons de rattes Wistar traitées par l'AY 9944

Intake of tritiated thymidine by the embryos of Wistar pregnant rats treated by AY 9944 is significantly lowered. This decrease is parallel with the embryonic hypotrophy. Is there a causal relationship between the two phenomena?