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1.
Vet Comp Oncol ; 12(1): 58-66, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22577893

RESUMO

This prospective study evaluated the utility of bone marrow aspirates (BMAs) obtained from multiple sites for staging of canine lymphoma (LSA) and mast cell tumours (MCTs). Forty dogs (LSA, n = 24; MCTs, n = 16) were enrolled, but only 33 (82.5%) had diagnostic bone marrow (BM) aspirates obtained from two sites for inclusion in the study. Nineteen dogs with LSA were included, and 6 (31.6%) had BM involvement. Neoplastic lymphocytes were present in BM from both sites in all of these dogs. Fourteen dogs with MCTs were included, and 3 (21.4%) had BM involvement. Neoplastic mast cells were present at both sites in two dogs and at only one site in the third. These results indicate that BMAs from multiple sites may not be needed for accurate staging of canine LSA patients, but more studies evaluating the pattern of BM infiltration in dogs with high-grade MCTs are warranted.


Assuntos
Medula Óssea/patologia , Doenças do Cão/patologia , Linfoma/veterinária , Mastocitoma/veterinária , Estadiamento de Neoplasias/veterinária , Animais , Cães , Linfoma/patologia , Mastocitoma/patologia , Estadiamento de Neoplasias/métodos
2.
Vet Pathol ; 49(5): 870-5, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21878681

RESUMO

An intact, 8-year-old, male Golden Retriever dog was presented for evaluation of a nasal mass and approximately 30 firm, raised, variably ulcerated dermal and subcutaneous masses. Histopathology of both nasal and multiple skin masses revealed multiple nonencapsulated, infiltrative masses comprising clusters, anastomosing trabeculae, and packets of neoplastic, round to ovoid, hyperchromatic cells with marked nuclear molding. Surrounding the neoplastic cells was a marked stromal response in which many of the spindle-shaped cells expressed muscle-specific actin and had ultrastructural features consistent with myofibroblasts. A literature search indicates that this is the first report in a peer-reviewed journal of cutaneous metastasis of a nasal neuroendocrine tumor in any domestic animal species.


Assuntos
Carcinoma Neuroendócrino/veterinária , Doenças do Cão/patologia , Neoplasias Nasais/veterinária , Neoplasias Cutâneas/veterinária , Pele/patologia , Animais , Carcinoma Neuroendócrino/patologia , Carcinoma Neuroendócrino/secundário , Diagnóstico Diferencial , Cães , Evolução Fatal , Imuno-Histoquímica/veterinária , Masculino , Microscopia Eletrônica de Transmissão/veterinária , Neoplasias Nasais/patologia , Pele/ultraestrutura , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/secundário
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