RESUMO
A recombinant strain of Nocardia mediterranei was found to produce a number of new rifamycins which are structurally related to rifamycin S, rifamycin W and rifamycin G. This strain was derived from two Nocardia mediterranei mutants by intraspecific recombination.
Assuntos
Nocardia/metabolismo , Recombinação Genética , Rifamicinas/biossíntese , Biotransformação , Fermentação , Nocardia/genética , Rifamicinas/isolamento & purificaçãoRESUMO
Papulacandin, a new antibiotic complex, active against Candida albicans and several other yeasts, was isolated from a strain of Papularia sphaerosperma. The fermentation, isolation, physico-chemical properties and biological activity of the five structurally related papulacandins A, B, C, D and E are reported. Papulacandin B, the main component, was assigned the formula of C47H64O17.
Assuntos
Antifúngicos/biossíntese , Fungos Mitospóricos/metabolismo , Animais , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Fenômenos Químicos , Química , Fermentação , Fungos/efeitos dos fármacos , Dose Letal Mediana , Espectroscopia de Ressonância Magnética , CamundongosRESUMO
Conductivity changes in the medium of cultured soybean (Glycine max L.) cells were shown to be strictly correlated with nitrate uptake and growth of the cultures. A continuous record of the conductivity was used as a simple and reliable method of determining specific growth stages and concomitant peaks in the activities of nitrate reductase and phenylalanine ammonia-lyase.
