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4.
Cureus ; 13(3): e14140, 2021 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-33927942

RESUMO

We report a case of a complex skin and soft tissue infection caused by Scedosporium apiospermum complex and Neisseria spp. following a dog bite. While Neisseria skin and soft tissue infections after dog bites have been reported, only one case of subsequent infection caused by Scedosporium spp. has been noted in the literature. To the best of our knowledge, this is the first reported case of coinfection of these particular organisms following a dog bite.

7.
J Cutan Pathol ; 47(10): 946-949, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32352174

RESUMO

Lichenoid granulomatous dermatitis (LGD) is a histopathologic pattern with a band-like lymphocytic infiltrate, typical of lichenoid dermatitis, combined with dermal histiocytes and granulomatous inflammation. Prior reports have described cases of LGD caused by non-tuberculous mycobacteria, with evidence of intralesional acid-fast bacilli or mycobacterial DNA. Herein, we report a patient with pulmonary and extrapulmonary Mycobacterium tuberculosis infection who developed LGD. No evidence of M. tuberculosis was detected within the cutaneous lesions, suggesting a potential delayed-type hypersensitivity reaction to tuberculosis.


Assuntos
Erupções Liquenoides/patologia , Espondilite/complicações , Tuberculose Cutânea/complicações , Tuberculose Cutânea/patologia , Adolescente , Adulto , Dermatite/patologia , Diagnóstico Diferencial , Testes Diagnósticos de Rotina/métodos , Feminino , Granuloma/patologia , Humanos , Hipersensibilidade Tardia/imunologia , Hipersensibilidade Tardia/patologia , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/isolamento & purificação , Espondilite/diagnóstico , Espondilite/microbiologia , Espondilite/patologia , Tuberculose/complicações , Tuberculose/microbiologia , Tuberculose/patologia , Tuberculose Cutânea/microbiologia
8.
Cureus ; 12(2): e7127, 2020 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-32140372

RESUMO

Infection-related glomerulonephritis (IRGN) is an immune complex-mediated glomerulonephritis (GN), often preceded by infection with subsequent recovery of renal function after the resolution of the infection. C3 deposition in the absence of immune complex deposits can be seen in patients with IRGN, but with the emergence of C3 glomerulonephritis (C3GN), the distinction is difficult as the clinical and pathological presentation may be similar. However, their treatment and clinical course vary significantly. A 64-year-old man with a history of hypertension and bioprosthetic aortic valve presented to the Emergency Department with left upper quadrant (LUQ) pain and a purpuric rash on bilateral lower extremities. The patient became septic, and further workup during the hospitalization revealed endocarditis secondary to Streptococcus viridans. On admission, the patient had acute kidney injury (AKI) with a serum creatinine of 3.79 mg/dl, which peaked at 5.72 mg/dl during the hospitalization. Renal biopsy demonstrated segmental necrotizing glomerulonephritis on light microscopy, predominant C3 deposition on immunofluorescence (IF) staining, and mesangial and paramesangial deposits on electron microscopy. This histologic picture can be seen both in IRGN and C3GN. The patient was treated with intravenous ceftriaxone for six weeks for endocarditis and the kidney injury was managed with supportive care. The patient's renal function improved and complement levels normalized, supporting the diagnosis of IRGN retrospectively. IRGN can mimic C3GN, and evaluation for alternate pathways of the complement system may be warranted in patients with atypical presentation of IRGN.

11.
Cureus ; 12(12): e11905, 2020 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-33415056

RESUMO

Dermatobia hominis, also known as the human botfly, is an insect native to Central and South America that is known to parasitize both human and animal hosts through cutaneous infestation by its developing larvae. While human botfly myiasis has been commonly diagnosed through dermatologic findings, the presenting lesions and associated symptoms can be non-specific and often misconstrued as other more common cutaneous diagnoses. Here, we present a case of botfly myiasis of the scalp in which ultrasound was utilized to visualize the larvae and confirm the diagnosis prior to larval removal. In this report, we discuss our patient's presentation, ultrasound imaging, and clinical course/treatment in order to convey how ultrasound imaging, when available, is a valuable tool in establishing the diagnosis of human botfly myiasis.

15.
Transpl Infect Dis ; 20(6): e12990, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30184311

RESUMO

Solid organ transplant patients are well established to be at risk of herpes simplex virus and varicella zoster virus infection and reactivation. We present a case of a 41-year-old woman with a history of pancreas and renal transplant who presented with what appeared to be disseminated herpes simplex virus or varicella zoster virus induced rash, but who was ultimately diagnosed and treated as linear IgA bullous dermatosis. This case alerts physicians to other non-infectious dermatoses as a cause of vesiculobullous rash in solid organ transplant patients.


Assuntos
Terapia de Imunossupressão/efeitos adversos , Imunossupressores/efeitos adversos , Transplante de Rim/efeitos adversos , Dermatose Linear Bolhosa por IgA/diagnóstico , Transplante de Pâncreas/efeitos adversos , Adulto , Dermatite Herpetiforme/diagnóstico , Diabetes Mellitus Tipo 1/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Terapia de Imunossupressão/métodos , Falência Renal Crônica/cirurgia , Dermatose Linear Bolhosa por IgA/induzido quimicamente , Dermatose Linear Bolhosa por IgA/patologia , Prednisona/efeitos adversos , Pele/patologia , Tacrolimo/efeitos adversos
16.
Respir Med Case Rep ; 25: 30-32, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29998055

RESUMO

Hypereosinophilic syndrome (HES) is characterized by a persistently elevated eosinophil count associated with eosinophil-related end-organ damage and thromboembolic events, in the absence of an identifiable cause. We present a case of idiopathic HES with evidence of peripheral and tissue eosinophilia while on high dose prednisone, associated with muscle tension dysphonia, colitis, and jackhammer esophagus. The patient was treated with the interleukin-5 inhibitor, Mepolizumab, with resolution of symptoms including dyspnea, diarrhea and dysphonia.

17.
J Cutan Pathol ; 45(6): 412-415, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29484692

RESUMO

The objective of our study was to establish a detailed photomicrographing protocol for pathologists and dermatopathologists using standard overhead camera and image editing packages. Through a trial-and-error approach we devised a series of steps that comprise our photomicrographing protocol. Descriptive and interpretive data analyses were performed to highlight how each step improves tinctorial quality of digital photomicrographs.


Assuntos
Dermatologia/métodos , Processamento de Imagem Assistida por Computador/métodos , Patologia/métodos , Fotomicrografia/métodos , Telefone Celular , Humanos , Software
18.
J Cutan Pathol ; 44(12): 1064-1069, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28869660

RESUMO

Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.


Assuntos
Calciofilaxia/patologia , Falência Renal Crônica/complicações , Úlcera da Perna/patologia , Leucemia Linfocítica Crônica de Células B/patologia , Pseudoxantoma Elástico/patologia , Idoso de 80 Anos ou mais , Biópsia , Vasos Sanguíneos/patologia , Calciofilaxia/complicações , Diagnóstico Diferencial , Tecido Elástico/patologia , Feminino , Humanos , Leucemia Linfocítica Crônica de Células B/complicações , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Pessoa de Meia-Idade , Pseudoxantoma Elástico/complicações
19.
J Cutan Med Surg ; 16(6): 436-7, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23149201

RESUMO

BACKGROUND AND OBJECTIVE: Neurofibromatosis (NF) is a neurocutaneous disorder with seven subtypes;segmental NF-1 is characterized by neurofibromas and or café-au-lait macules in one or more dermatomes, primarily the thorax and abdomen. We present the rare case of a 36-year-old African-American female with isolated, multiple soft nodules in a linear configuration on the plantar and dorsal surfaces of the left foot. CONCLUSION: This is the first report of isolated segmental NF-1 in a unique linear pattern confined to the L5 dermatome.


Assuntos
Dermatoses do Pé/patologia , Plexo Lombossacral , Neurofibromatoses/patologia , Pele/inervação , Adulto , Feminino , Humanos
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