RESUMO
The aim of this study was to evaluate the early effects of high and low-osmolar contrast media on glomerular function in rats by using a new method based on the measurement of the urinary excretion of 99mTc-DTPA. Thirty-six Sprague-Dawley male rats were examined: nine rats were injected with diatrizoate (ionic high-osmolar contrast medium), nine rats with iohexol (nonionic low-osmolar contrast medium), and nine rats with saline as controls. The urinary excretion of 99mTc-DTPA in the first minutes after i.v. injection was assumed as an index of glomerular filtration rate. A lower urinary excretion of 99mTc-DTPA was found in rats treated with contrast media in comparison with control rats. This effect was more evident after diatrizoate but was statistically significant also after iohexol. In conclusion, a reduction in the glomerular filtration rate probably occurs in the first few minutes after contrast media administration. The measurement of urinary excretion of 99mTc-DTPA could be a simple method to detect acute glomerular effects due to contrast media or to other drugs.
Assuntos
Meios de Contraste/toxicidade , Diatrizoato/toxicidade , Iohexol/toxicidade , Iopamidol/toxicidade , Glomérulos Renais/efeitos dos fármacos , Pentetato de Tecnécio Tc 99m/urina , Animais , Modelos Animais de Doenças , Taxa de Filtração Glomerular/efeitos dos fármacos , Injeções Intravenosas , Masculino , Concentração Osmolar , Ratos , Ratos Sprague-Dawley , Valores de Referência , Pentetato de Tecnécio Tc 99m/sangue , Fatores de TempoAssuntos
Diatrizoato de Meglumina/toxicidade , Iohexol/toxicidade , Iopamidol/toxicidade , Nefropatias/induzido quimicamente , Túbulos Renais/efeitos dos fármacos , Adulto , Idoso , alfa-Globulinas/metabolismo , Animais , Humanos , Radioisótopos do Iodo , Nefropatias/metabolismo , Túbulos Renais/metabolismo , Masculino , Pessoa de Meia-Idade , Ratos , Ratos EndogâmicosAssuntos
Rim/metabolismo , Proteínas/metabolismo , Animais , Ânions , Aprotinina/metabolismo , Cátions , Humanos , Rim/diagnóstico por imagem , Masculino , Peso Molecular , Cintilografia , Ratos , Ratos Endogâmicos , TecnécioAssuntos
Túbulos Renais Proximais/metabolismo , Proteínas/metabolismo , Animais , Aprotinina/metabolismo , Grupo dos Citocromos c/metabolismo , Interferon alfa-2 , Interferon-alfa/metabolismo , Radioisótopos do Iodo , Túbulos Renais Proximais/diagnóstico por imagem , Cinética , Masculino , Peso Molecular , Muramidase/metabolismo , Cintilografia , Ratos , Ratos Endogâmicos , Proteínas Recombinantes , Distribuição TecidualRESUMO
Renal artery embolism is not a rare occurrence, especially in patients with valvular heart disease, but the early diagnosis of this condition is infrequently accomplished. We report the clinical and laboratory data of 2 patients with valvular heart disease who presented with unilateral renal artery embolization. The usefulness of the determination of serum and urinary enzymes and renal function tests is discussed. We propose that these parameters support an earlier and more accurate diagnosis of renal artery embolism.