RESUMO
Extrapulmonary manifestations of Legionella pneumophilia infection are infrequent. Cardiac involvement can occur. We observed an unusual case which led to acute pericarditis and reviewed the literature on cardiac involvement, particularly pericarditis, in patients which legionellosis.
Assuntos
Doença dos Legionários , Pericardite/microbiologia , Doença Aguda , Adulto , Humanos , MasculinoRESUMO
The authors report a case of american pulmonary histoplasmosis discovered by chance on a chest radiograph in a non immunocompromised patient, back from a stay in French Guyana. Confronted with the negativity of usual mycotic research, diagnosis has been made thanks to wedge excision by video-assisted thoracic surgery. The authors briefly sum up the recent facts regarding this imported infection, stressing the interest of a direct approach by surgical practices not very invasive that allow to eliminate with certainty neoplasm or tuberculosis.
Assuntos
Histoplasmose/diagnóstico por imagem , Pneumopatias Fúngicas/diagnóstico por imagem , Adulto , Histoplasmose/diagnóstico , Histoplasmose/cirurgia , Humanos , Pneumopatias Fúngicas/diagnóstico , Pneumopatias Fúngicas/cirurgia , Masculino , RadiografiaRESUMO
Coagulation disorders frequently complicate cancer. We observed a patient with lung cancer who developed recurrent thromboembolism. Hypercoagulation was induced by tumor cells via different factors enhancing coagulation. Heparinotherapy, or in certain cases oral anticoagulants, are often ineffective.
Assuntos
Neoplasias Pulmonares/complicações , Tromboembolia/etiologia , Anticoagulantes/uso terapêutico , Humanos , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Recidiva , Tromboembolia/sangue , Tromboembolia/tratamento farmacológicoRESUMO
The ELSA-CA 125 II is a second-generation radioimmunoassay for the quantification of CA 125 in serum. In a multicentre study involving 49 follow-ups of patients with ovarian cancers, and 880 other patients, 2.8% of healthy persons, 25% of 149 patients with benign gynaecological diseases and 39% of 82 patients with benign non-gynaecological diseases had CA 125 levels above 35 U/ml. Using the 35 U/ml cut-off, sensitivities among epithelial ovarian cancers were found to be 85% in serous tumors, 41% in mucinous tumors and 83% in other types. During follow-up of patients with serous ovarian cancers, we observed an equivalent behaviour of both assays--first- and second-generation--with the clinical evolution. We also compared results obtained with other assays commercially available; these were significantly different when a polyclonal antibody was used in the sandwich assay.
Assuntos
Antígeno Ca-125/sangue , Adolescente , Adulto , Fatores Etários , Idoso , Ensaio de Imunoadsorção Enzimática , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Ovarianas/sangueRESUMO
pS2 protein assay was performed with Elsa-pS2 kit (CIS-Biointernational) on a group of 1,065 patients with operable breast cancer who underwent breast surgery in the years 1982 through 1990. The median follow-up was 57 months. This group included exclusively infiltrating ductal carcinoma with primary surgery. Age mean was 58 yr; T0-T1, 33.6%; T2-T4, 66.4%; Differentiation grade I, 29%; node negative, 53%; estrogen receptor (ER) positive, 62.4%; progesterone receptor (PR) positive, 55.2%; mean tumor size, 2.4 cm; local recurrence, 5.2%; metastasis, 17.5%. pS2 values varied from 0.1 to 707 ng/mg of cytosol protein (median, 5.6; mean 24.5; 95th percentile 112 ng/mg p). There was no significant relationship between the mean level of pS2 and age, tumor size, nodal status, whereas pS2 was related to histological grade (P < 10(-3)), ER (P < 10(-5)), and PR (P < 10(-5)). By using 2 ng/mg p as pS2 cutoff, 77/391 (19.7%) of ER+PR+ tumors were pS2-, and 122/345 (35.4%) of ER-PR-tumors were pS2+; with this cutoff, a strong relationship existed between pS2 and overall survival, but not between pS2 and relapse-free survival. With Cox multivariate analysis, pS2 protein was classified after lymph node status, histological size, ER, differentiation grade, age, clinical stage, PR. In patients with axillary lymph node involvement (N+), pS2 status could discriminate between good and bad prognosis, specially for patients with small tumors (< 2 cm) and with less than seven invaded nodes. This study showed that pS2 protein was a poor prognostic factor in comparison with classical factors.
Assuntos
Neoplasias da Mama/sangue , Carcinoma Ductal de Mama/sangue , Estrogênios/sangue , Proteínas de Neoplasias/sangue , Proteínas , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Carcinoma Ductal de Mama/patologia , Carcinoma Ductal de Mama/cirurgia , Feminino , Seguimentos , Humanos , Técnicas Imunoenzimáticas , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Valores de Referência , Taxa de Sobrevida , Fator Trefoil-1 , Proteínas Supressoras de TumorRESUMO
Plasma and fractionated lipoproteins from 40 Lewis Lung Carcinoma grafted mice were tested from the first day up to the fatal issue by biochemical analyses and water suppressed 1H NMR spectroscopy. We have confirmed first, that the 1H NMR spectra of plasma lipoproteins are modified by the tumoral state and could provide a useful marker of the disease as long as they are used for individual follow-up with appropriate spectral parameters. Using fractionated lipoproteins we have demonstrated secondly, that the observed spectral modifications do not result from a specific cancer lipoprotein but from quantitatively modified ratio between Very Light Density Lipoproteins and High Density Lipoproteins.
Assuntos
Carcinoma/sangue , Lipoproteínas/sangue , Neoplasias Pulmonares/sangue , Espectroscopia de Ressonância Magnética , Animais , Carcinoma/patologia , Colesterol/sangue , HDL-Colesterol/sangue , Lipoproteínas VLDL/sangue , Neoplasias Pulmonares/patologia , Masculino , Camundongos , Camundongos Endogâmicos DBA , Triglicerídeos/sangue , Células Tumorais CultivadasRESUMO
Fourteen hyperthyroid subjects were studied between 3 and 141 days. The reduction of thyrotoxicosis is rarely obtained (2 cases), mainly because on the one hand, correct plasma lithium level (0.7-1.2 mEq/L) is rarely obtained (3 cases only), on the other hand because a high dose of lithium is required, perhaps owing to high clearance of lithium in thyrotoxicosis. The indications of lithium use in thyrotoxicosis are reviewed.
Assuntos
Hipertireoidismo/sangue , Lítio/farmacologia , Hormônios Tireóideos/sangue , Tireotropina/sangue , Adulto , Idoso , Feminino , Humanos , Lítio/administração & dosagem , Masculino , Pessoa de Meia-Idade , Tiroxina/sangue , Fatores de Tempo , Tri-Iodotironina/sangue , Tri-Iodotironina Reversa/sangueRESUMO
The authors studied seric IgE levels in 79 patients with scabies: 48 p. 100 had significant elevated concentration of IgE (greater than 300 U. I./ml) (p less than 0,001). This is the fact of scabies infestation and is not the result of internal parasitic infestation, associated illnesses or atopic disease. There is a statistically significant correlation between high IgE levels and degree of extension (p less than 0,1) and, overall, eczematization (or) and superinfection (p less than 0,001).
Assuntos
Imunoglobulina E/análise , Escabiose/imunologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escabiose/patologiaRESUMO
Persistence of a post-partum galactorrhea with an hyper-prolactinaemia leads to charge clonidin, an hypotensive-drug. When clonidine is stopped, galactorrhea and hyper-prolactinaemia case. Explanation of the role of the drug is uneasy.
Assuntos
Clonidina/efeitos adversos , Galactorreia/induzido quimicamente , Transtornos da Lactação/induzido quimicamente , Prolactina/sangue , Transtornos Puerperais/induzido quimicamente , Adulto , Clonidina/uso terapêutico , Feminino , Humanos , Hipertensão/tratamento farmacológico , GravidezRESUMO
Serum concentrations of Thyroxine (T4), triiodothyronine (T3) free thyroxine index (F.T.I.) and TSH response to TRH were evaluated in 55 Graves' diseases treated by Carbimazole. There is a good correlation between serum thyroid hormones and clinical state: 83,7% for T4; 79,5% for T3; on the other hand there is a discrepancy between T3 and T4 in many cases and between delta TSH and T4 (47%) or T3 (46%). The decrease of T4 occurs before that of T3: 46,6% normal at the 4th month and 72,5% at the 9th month for T4 against 41% and 50% for T3. At the end of the treatment 96,4% of patients are clinically normal but 20% of them remain with T3 and T4 values above normal.
Assuntos
Carbimazol/uso terapêutico , Doença de Graves/sangue , Hormônios Tireóideos/sangue , Hormônio Liberador de Tireotropina , Doença de Graves/tratamento farmacológico , Humanos , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangueRESUMO
Seventy tests of stimulation with hypothalamic thyreotrophic hormone liberation factor, and 35 bromocriptine inhibition tests were carried out on a routine basis in patients with latent or frank hyperprolactinaemia. Pathological hyperprolactinaemia does not have a single clinical pattern: frank, it takes the form either of an exteriorised pituitary adenoma (14 cases), or of an amenorrhoea-galactorrhoea syndrome with or without micro-adenoma (12 cases); latent, it takes the form either of isolated amenorrhoea (17 cases) or of dysovulatory sterility (16 cases). Amongst the dynamic tests available, it is worthwhile to make a choice, and in the case of frank hyperprolactinaemia, the authors propose use of the bromocriptine inhibition test in the first instance. The TRH test is reserved for verification of the results of neurosurgery. As far as latent hyperprolactinaemia is concerned, it may be identify only by the TRH test, with the resultant possibility of specific treatment.