[Treatment efficacy in acute intestinal infections, chronic diseases of the gastrointestinal tract and viral hepatitis B using large doses of Russian Bifidumbacterin-forte]. / Effektivnost' lecheniia ostrykh kishechnykh infektsii, khronicheskikh boleznei zheludochno-kishechnogo trakta i virusnogo gepatita B bol'shimi dozami otechestvennogo Bifidumbakterina forte.

Until now viral and bacterial acute intestinal infections have a high percent in the whole structure of modern intestinal disorders morbidity. Taking into consideration inefficacy of antibacterial treatment in a number of cases, probiotics with antagonist effect on a wide range of bacteria have found a wide usage. This study proves clinic and morphological efficacy of large doses Bifidumbacterinum forte for the treatment of the diseases mentioned. The patients of the test group demonstrated a relation dyspeptic disturbances, improvement of total state in a shorter period than the patients of control group.

[Pathomorphology of the large intestinal mucosa in acute infectious colitis]. / Patomorfologiia slizistoi obolochki tolstoi kishki pri ostrykh infektsionnykh kolitakh.

634 biopsies of distal colon mucosa from 393 patients with acute intestinal bacterial and viral infections were studied histologically, histochemically and morphometrically. Acute catarrhal or catarrhal-hemorrhagic inflammation was found regardless of the colitis etiology (Shigella, Salmonella, Campylobacter, rotavirus). The most pronounced inflammation was in shigellosis and minimal one in rotavirus infection. Marked eosinophilic infiltration of the epithelium and tunica propria was observed in colonic contamination with C. pylori. Correlation analysis between morphometric indices in shigellosis and salmonellosis revealed a decrease in the number of strong functional links and the appearance of new ones indicating morphofunctional derangement.

[Augmentin in the clinical picture of infectious diseases]. / Augmentin v klinike infektsionnykh boleznei.

Augmentin is a new combination manufactured by Smith Kline Beecham (Great Britain). It is composed of amoxycillin and clavulanic acid and has antibacterial activity. Augmentin was used in clinical trials in the therapy of 50 adult patients with suppurations after surgical operations on the organs of the abdominal cavity, general staphylococcal infections, pneumonia and prophylactically during the preoperative period. It was also used in the treatment of 30 children patients with bronchopulmonary affections and inflammatory otorhinolaryngological diseases. The clinical trials were performed in the Clinic of Infectious Diseases of the N. G. Gabrichevskii Moscow Research Institute of Epidemiology and Microbiology. For comparison ampicillin was used in the trials. Augmentin was shown to be an efficient formulation with antibacterial activity which could be successfully used in the parenteral therapy of severe affections due to organisms sensitive to it. In the treatment of the children patients with pneumonia augmentin by its therapeutic efficacy proved to be superior to ampicillin. The tolerance of augmentin was good.

[Sensitivity of the pathogen of Campylobacter infection to various antibiotics]. / Chuvstvitel'nost' vozbuditelei kampilobakterioza k nekotorym antibiotikam.

Antibiotic sensitivity of 21 Campylobacter strains isolated from humans, monkeys and birds with diarrhea was assayed and the findings are presented. It was shown that all the isolates were highly sensitive to ofloxacin, pefloxacin, ciprofloxacin, josamycin, pipemidinic acid and amoxyclav (a combination of amoxycillin and clavulanic acid). The predominating majority of the strains were resistant to rifampicin, amoxycillin and phosphomycin. The majority of the cultures were sensitive to erythromycin and roxithromycin while some of the isolates were resistant to them which could be used as an additional biological characteristic of Campylobacter cultures and considered in choosing agents for antibiotic therapy.

[Patho-anatomic changes in rotaviral gastroenteritis in children]. / Patologoanatomicheskie izmeneniia pri rotavirusnom gastroénterite u detei.

Two children (a 6-month-old girl and a 9-month boy) died from Rotavirus gastroenteritis as evidenced by virological, electron microscopic, and immune fluorescence studies of intestinal tissue. Histological and morphometric examinations of the small intestine revealed acute diffuse enteritis with enlarged and shortened villi, infiltration of intrinsic plates with lymphocytes, plasma cells and macrophages, enhanced mitotic activity of epitheliocytes and their increased lymphocyte-induced infiltration. The hepatic tissue showed central lobular fatty infiltration. The above changes should be regarded as manifestations of Rotavirus infection. Pneumonia detected in one of the children had been caused by influenza infection.

[Isolation of the human rotavirus in a cell culture of green monkey kidneys]. / Vydelenie rotavirusa cheloveka na kul'ture kletok pochek zelenykh martyshek.

Properties of a virus isolated from a patient with rotavirus gastroenteritis (the diagnosis verified by direct electron microscopy) were studied. The virus was identified as a rotavirus in tissue culture neutralization and complement fixation tests. It was shown to replicate through a significant number of passages in continuous cell cultures (Vero, RH) as well as in primary cell cultures of human and animal origin (human embryo kidney, green monkey kidney); some features associated with rotavirus propagation are described.

[Use of the agar diffusion precipitation method for detecting rotavirus antigen]. / Ispol'zovanie metoda diffuzionnoi pretsipitatsii v agare dlia obnaruzheniia rotavirusnogo antigena.

The possibility of rotavirus detection in feces of patients with acute enteric diseases by the agar gel diffusion (AGD) test was studied. The effectiveness of this method was compared with that of the standard method, direct electron microscopy. Both methods showed good correlation of the results, but the AGD test is methodically much simpler which recommends it for diagnosis of rotavirus infection. Rotavirus-specific hyperimmune calf serum may by used as a serological diagnostic preparation for the detection of human rotavirus antigen.