Engineering yeast for industrial-level production of the antimalarial drug artemisinin.

Artemisinin-based combination therapies are the gold standard treatment for uncomplicated malaria. A seminal study by Paddon et al. detailed an efficient approach for producing artemisinic acid from engineered yeast and its conversion to artemisinin, and demonstrated how to use metabolic engineering and synthetic biology for the production of bioactive compounds.

An outbreak of acute hepatitis A infection in rural Saudi Arabia.

In areas of hyperendemicity of hepatitis A virus (HAV) infection, acquisition of immunity occurs relatively early in life. In such populations epidemic outbreaks are rare. A recent HAV infection outbreak occurred in the Al-Dahnah district in Saudi Arabia. In thirty day period, 23 children and adolescents were diagnosed by clinical examination. 19 of these were positive for IgM anti-HAV. Concomitant acute infections with the Epstein Bar Virus (EBV) was documented in 4 of these patients. A limited epidemiological survey suggested that the source of infection might have been a contamination of one of the tankers which delivered water supplies to the various houses. In a transitional period of development the rapid improvement in socio economic status and standards of living may increase the susceptible pool. Therefore a greater surveillance is needed to identify and contain such possible outbreaks.