Effects of prophylactic intravenous immunoglobulin-G therapy on humoral and cellular immune components and their functions in burned patients.

In this study on patients with thermal trauma, we examined the effects of standard therapy plus prophylactic polyclonal immunoglobulin G (IgG) treatment on humoral and cellular contents, cell phenotype and function of the immune system, and compare these with those found in patients receiving only standard therapy. The quantitative, peripheral-blood mononuclear cell panel shows a decrease in the total number of T-lymphocytes and an increase in the natural killer (NK) cells of standard therapy patients 3 weeks following the burn. We found that intravenous IgG treatment does not have an important effect on T lymphocytes and the proportion of their subpopulations, but rather causes a significant decrease in the number of B lymphocytes and an increase in the number of NK cells. When comparing the DNA synthetic response to mitogenic and antigenic stimuli in patient's T and B lymphocytes using phytohaemagglutinin, pokeweed mitogen or allogenic mixed cells in separate in vitro cell cultures, the highest suppressive effect of thermal trauma is seen in the cells derived from the patients who had been given prophylactic IgG therapy. The presented data confirm that thermal trauma causes an immunosuppressive effect and indicate that prophylactic polyclonal IgG therapy increased the quantitative and functional suppression of the specific immune system while additionally increasing the cellular levels of the non-specific immune system, each system having been previously stimulated by thermal trauma.

[Investigation of relation between anxiety and TMJ dysfunction in dental students]. / Dis hekimligi ögrencileri arasinda TME disfonksiyonu ile anksiyete arasindaki iliskinin arastirilmasi.

In this study relation between Temporomandibular Joint Dysfunction (TMJD) and anxiety was investigated. For this purpose 2 different questionnaires were given to a total of 360 students (192 girls and 160 boys) aiming to determine the anxiety levels and their tendency to develop TMJD. After obtaining the results from the questionnaire for TMJD, the students are first divided into 2 main groups according to have TMJD or not, then into 5 consisting of "bruxism", "occlusion", "trauma", "combined" and "normal" groups. The groups were compared with each other for the relation between anxiety, TMJD and age. A positive relationship was demonstrated between anxiety and TMJD but statistically significant correlation wasn't found between age and TMJD. Also, the results didn't show any correlation between bruxism and anxiety levels.