Serum Vitamin D and Zinc Levels in Children with Urinary Tract Infection without Confounding Factors: A Case-Control Study.

Background: Urinary tract infections (UTIs) are extremely prevalent bacterial infections among children. They have numerous potential causes. Without proper diagnosis and treatment, UTIs can lead to serious complications in children, including impaired growth, high blood pressure, protein in urine, and eventual chronic kidney disease. Zinc and vitamin D in sufficient concentrations help to maintain the health of the immune system. Therefore, their deficiency can cause various infections. Several factors can contribute to the development of UTIs. This article deals with the role of zinc and vitamin D as immune markers in UTI in children without other risk factors. Methods: In this case-control study, serum zinc and vitamin D levels without any other risk factors were examined in 40 healthy children and 40 children with UTIs. Data analysis was done through SPSS 26 using the chi-square, the Fisher's exact, and independent t tests. Results: The study findings demonstrated a statistically significant distinction between the 2 groups regarding serum vitamin D and zinc levels (P < 0.001); 80% of children with UTIs and 17.5% in the healthy group had vitamin D deficiency. Also, 60% of the urinary infection group had zinc deficiency, whereas 17.5% of the healthy group had it. Conclusion: Low serum zinc and vitamin D levels may increase susceptibility to pediatric UTI. Given the data, supplementation with zinc and vitamin D could play a significant role in treating active infections and preventing recurrence in susceptible children.

Design, implementation, and evaluation of a virtual pulmonary rehabilitation training course for medical interns in COVID-19.

Pulmonary rehabilitation has an influential role in improving the symptoms, reducing subacute and chronic complications, and increasing the performance of patients with COVID-19. Medical interns can play an essential role in training patients. Since, at the time of the research, these concepts were not in the general medical curriculum in Iran, the interns were not trained in this field. This study aimed to design, implement, and evaluate the virtual training course for pulmonary rehabilitation for medical interns in the COVID-19 crisis. A cross-sectional study (with an instructional design approach) was conducted at an academic center in 2021 on 25 medical interns. The newly designed educational content included multimedia files and educational videos offered to the participants. The data collection tools were pre- and post-test, attitude, and satisfaction evaluation questionnaires. Data were analyzed using SPSS (one-sample and paired t-test). The average age of the participants was 26.24 ± 0.92, and most were women (14 (56%)). The average knowledge score after the course (18.52 ± 4.44) compared to before (11.12 ± 2.38) was significant (P < 0.001). The average score of attitudes (55.04 ± 6.49) and satisfaction (92.92 ± 10.69) had a significant difference (P < 0.001 and P < 0.001) and indicated the desirability of the course. Considering the results of this course in improving students' knowledge, attitude, and satisfaction, it is suggested to add this topic to the general medical curriculum (pulmonary or infectious diseases courses).

Effects of crocin on inflammatory biomarkers and mental health status in patients with multiple sclerosis: A randomized, double-blinded clinical trial.

BACKGROUND: Multiple sclerosis (MS), as a demyelinating disease correlated with inflammation and oxidative stress, affects the central nervous system and causes a wide range of complications, including psychiatric disorders. Considering the anti-inflammatory and antioxidant properties associated with the bioactive components of saffron, such as crocin (trans-crocetin bis(ß-d-gentiobiosyl) ester), and their potential impact on ameliorating psychiatric symptoms, our study aimed to investigate the effect of crocin on biomarkers of inflammation, oxidative stress, and mental health, e.g., depression and anxiety in individuals with MS. METHOD: Patients with MS were randomized into two groups, taking either 15 mg crocin tablets twice a day (n = 25; 30 mg/day) or placebo tablets (n = 25) for 8 weeks. The valid and reliable Beck depression and anxiety scale questionnaire was recorded, and fasting blood samples were collected to measure biomarkers, including high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and nitric oxide (NO) at baseline and week 8 following the intervention. RESULTS: The data analysis using ANCOVA showed that supplementation with crocin for 8 weeks significantly lowered hs-CRP levels (p-value= 0.01). In addition, within-group comparisons showed crocin significantly decreased anxiety (p-value= 0.01). However, crocin did not affect serum MDA and NO after 8 weeks of intervention. CONCLUSION: Our findings suggest that crocin may keep promise in attenuating inflammation, evidenced by reducing hs-CRP in patients with MS. However, supplementation for 8 weeks may not be sufficient to improve mental health, and future clinical studies with higher sample sizes and various doses and durations are recommended.

Therapeutic role of curcumin and its novel formulations in gynecological cancers.

Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to improve efficacy of the treatment process and patients' quality of life, searching for novel adjuvant treatments is highly warranted. Curcumin, a promising natural compound, is endowed with numerous therapeutic potentials including significant anticancer effects. Recently, various investigations have demonstrated the anticancer effects of curcumin and its novel analogues on gynecological cancers. Moreover, novel formulations of curcumin have resulted in further propitious effects. This review discusses these studies and highlights the possible underlying mechanisms of the observed effects.