La investigación operativa en las Ciencias de la Salud: ¿reconocemos estas técnicas en la literatura actual? / Operational research in the Health Sciences: Are these techniques appreciated in the current literature?

El objetivo de este trabajo es presentar aplicaciones de la investigación operativa en las Ciencias de la Salud, tanto en el campo de la organización y gestión de recursos sanitarios como en el campo de la prevención, detección y tratamiento de enfermedades. Nos centraremos en la aplicación, sin entrar en detalles técnicos de los modelos matemáticos ni de los métodos de resolución

The aim of this article is to present the uses of operational research in the health sciences, both in the field of the organisation and management of health resources and in the field of prevention, detection and treatment of diseases. we concentrate on application, without entering into the technical details of the mathematical models or the methods of resolution

[Operational research in the Health Sciences: Are these techniques appreciated in the current literature?]. / La investigación operativa en las ciencias de la salud: reconocemos estas técnicas en la literatura actual?

The aim of this article is to present the uses of operational research in the health sciences, both in the field of the organisation and management of health resources and in the field of prevention, detection and treatment of diseases. we concentrate on application, without entering into the technical details of the mathematical models or the methods of resolution.

Marcadores tumorales procesos ginecológicos benignos / Tumor markers in benign gynecologic diseases

La determinación de marcadores tumorales se emplea como prueba complementaria en el diagnóstico de algunas neoplasias. Cifras muy elevadas se asocian casi invariablemente a neoplasias malignas. Presentamos el caso de una paciente en la que el conjunto de datos analíticos, sobre todo la importante elevación de marcadores tumorales, y exploratorios orientaron hacia un diagnóstico de malignidad que condujo a la realización de cirugía radical. Únicamente el estudio histopatológico diferido de toda la pieza demostró la benignidad del proceso. Tras el tratamiento los niveles de marcadores descendieron hasta su normalización. Se concluye que la presencia de marcadores tumorales muy elevados puede inducir a un diagnóstico erróneo de malignidad en el estudio de las masas ováricas (AU)

Minor tranquilizers in the treatment of aggression.

Clinical trials designed to evaluate the efficacy of drugs in human aggression have been scarce until recent years. The potential antiaggressive action of minor tranquilizers in humans has received little attention in spite of the claimed "taming effect" in some animal studies. A recent report examining the literature regarding the effects of benzodiazepines on animal models of aggressive behavior has pointed out the lack of consistency in such findings. Similar observations have been noted in humans where reduction in aggressive manifestations is contrasted with an increase in hostility in a few studies, as well as with the appearance of "paradoxical" rage reactions. Some variables that could account for such discrepancies have been advanced. They include, among others, dosage, acute vs. chronic drug administration, and possible qualitive differences among this group of agents. Individual variations as to presenting clinical picture, initial levels of anxiety and hostility, and personality types have also been mentioned. Implications of some of these findings for future clinical research are discussed. At present, a study designed to test the efficacy of two benzodiazepines, at dosages higher than those usually recommended, is being carried out in a population of anxious, aggressive-prone individuals with poor impulse control. Thus far, and in agreement with our previous clinical experience, we have not seen "paradoxical" rage and such high dosages have been well tolerated.