[Complex diagnosis of congenital cranial dysostosis in children]. / Kompleksnaia diagnostika vrozhdennykh kraniodizostozov u detei.

Ten patients (aged 3-15 years) with congenital cranial dysostosis were examined by a pediatrician, geneticist, gastroenterologist, neuropathologist, ophthalmologist, endocrinologist, and orthopaedist. In addition to the clinical signs characteristic of hereditary multiple developmental defects, the study revealed changes in the jaws and temporomandibular joint and local factors promoting the progress of deformations of the jaws. Manifest and inapparent pathological changes and dysfunctions in gastrointestinal organs were paralleled by dysfunctions of the central and autonomic nervous systems, risk of maxillofacial and general deformations, and signs of congenital disorders in calcium, lactic acid, and pyridoxine metabolism. The results necessitate analyses of the blood and urine and development of new methods for the diagnosis of congenital cranial dysostosis and improvement of methods for the correction of this condition.

[Preoperative bifidum-lactobacterin therapy in children with cleft lip and palate]. / Primenenie bifidum-laktobakterina v dooperatsionnom periode u detei s vrozhdennoi rasshchelinoi verkhnei guby i neba.

Microbiological and immunologic investigations of peripheric blood in 125 children were conducted. They determined a positive role of early correction with eubiotics (bifidum-lactobacterium) in children with congenital cleft lip and congenital cleft palate during 8-9 months before chiloplasty and uraniscoplasty. Using eubiotics results in normalization and restoration of the intestinal microflora, which leads to restoration of cellular and humoral immunity and to decreased rates of accompanying and postoperative complications.

[Diagnostic techniques in children with secondary deforming temporomandibular osteoarthrosis]. / Rezul'taty kompleksnogo obsledovaniia detei s vtorichym deformiruiushchim osteoartrozom visochno-nizhnecheliustnogo sustava.

The article presents the results of examination 135 children aged 2-15 years with deformities of maxillofacial system. Original screening methods of diagnosis of congenital disorders of metabolism were used. The signs of dismetabolic processes and morphofunctional disorders in gastrointestinal organs were found. These may indicate congenital and acquired genesis of metabolism-disturbances, which promote deforming of maxillofacial region and skeleton.

[Change in the drug-metabolizing function of the liver in patients in the postoperative period in relation to the type of anesthesia]. / Izmenenie farmakometaboliziruiushchei funktsii pechenii u bol'nykh v posleoperatsionnom periode v zavisimosti vida anestezii.

Anesthesia-dependent changes in pharmaco-metabolic liver function have been studied in patients operated on for cosmetic facial defects. It has been established that the postoperative period in patients subjected intraoperatively to general combined anesthesia and controlled lung ventilation was characterized by inhibited drug metabolism in the liver, which required correction of the drug doses to reduce the risk of side and toxic effects of pharmacotherapy. Patients operated on under local procaine anesthesia had no considerable changes in pharmaco-metabolic liver function in the postoperative period.

[The use of benzonal and saparal in the combined therapy of patients with acute inflammatory processes of the maxillofacial area]. / Ispol'zovanie benzonala i saparala v kompleksnoi terapii bol'nykh s ostrymi vospalitel'nymi protsessami cheliustno-litsevoi oblasti.

The efficacy of inductors and adaptogens (benzonal and saparal) in combined therapy of patients with acute maxillofacial inflammations was investigated. These agents were conducive to shortening of the treatment periods and prevented complications (chronic osteomyelitis). A sooner recovery of the disordered homeostatic constants of the body (microsomal monoxygenase activities, acetylation processes, nonspecific resistance, leukocytic index of intoxication) was achieved.

[The liver detoxification function and the nature of the adaptive reactions in patients of different ages with inflammatory processes of the maxillofacial area]. / Detoksikatsionnaia funktsiia pecheni i kharakter adaptatsionnykh reaktsii u bol'nykh razlichnogo vozrasta s vospalitel'nymi protsessami cheliustno-litsevoi oblasti.

Liver monooxygenase system activity, responsible for liver detoxication, was examined with the use of antipyrin test in children and adults suffering from maxillofacial inflammations, as was their nonspecific resistance of the body. The findings evidence that inflammatory diseases are associated with a considerable reduction of the body nonspecific resistance and with depression of the liver monooxygenase system, most marked in acute inflammations. The severity of liver detoxication function disorder is in inverse relationship with the status of the body nonspecific resistance; this factor essentially influences the length of therapy.

[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]. / Sostoianie mikrosomal'noi okislitel'noi sistemy pecheni krys s ostrym osteomielitom nezhnei cheliusti.

Duration of hexenal sleep and activity of main microsomal enzymes in hepatocytes were studied in experimental osteomyelitis of rat mandible. Within 7, 10 and 14 days after the osteomyelitis development content of cytochromes P-450 and b5 as well as activities of amidopyrine N-demethylase, aniline hydroxylase and NADPH cytochrome c reductase were decreased in liver cell microsomal fraction. As liver tissue monooxygenase enzymatic system is inhibited in osteomyelitis the elevated pharmacological activity and toxicity of drugs, metabolized in liver tissue, should be considered under conditions of practical use of these drugs.