[Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients]. / Testirovanie mutatsii genov BRCA1 i BRCA2 u 52 bol'nykh rakom molochnoi zhelezy.

The proportion of BRCA1/2 genes varies widely among populations. We investigated 52 cases of breast cancer: 24 cases of familial breast cancer, 22--early-onset (till 40 years) and 6--bilateral cancer. The frequency of carriers of mutations among familial cancer cases was 16%, among cases of disease till 40 years--9%. 538insC BRCA1 was the most common genetic mutation among hereditary cases of breast cancer.