[Unusual CT skull findings after preventive CNS treatment of acute leukemia in children]. / Auffällige CT-Befunde des Schädels nach präventiver ZNS-Behandlung akuter Leukämien bei Kindern.

CT examinations of the cranium were carried out among 15 children who had previously received cranial radiation and i.th. methotrexate during leukemia management. Surprisingly, 10 of 15 patients had abnormal CT findings. Only 2 of the 10 "CT-positive" children were clinically-neurologically conspicuous. The visible CT alterations of brain structure seemed especially marked and frequent the more time had elapsed since CNS-treatment. The most striking CT pathologica were found among children up to 5 years of age, who were also conspicuous through convulsions and delayed development.

[The virostatic effect of adenine-arabinoside monophosphate. Experimental findings and preliminary clinical experiences]. / Untersuchungen zur virostatischen Wirkung von Adenin-Arabinosid-Monophosphat.

Adenine arabinoside (Ara-A), a synthetic nucleoside, is an antiviral agent, which is effective against poxviruses and viruses of the herpes group. The monophosphate (Ara-AMP) has the great advantage of better solubility, compared to the parent compound. Experimental studies show the outstanding effect of Ara-AMP on the encephalitis by vaccinia-virus in white mice. Even after immunesuppression by total body irradiation, the survival rate of the Ara-AMP treated animals was significantly higher compared to the untreated controls. In experimental vaccinia-virus infections in rabbits, who had undergone total body irradiation. Ara-AMP has a favourable influence upon the course of the disease and the prognosis. Some clinical observations in children with immunesuppression, who suffered from generalized zoster of varicella-infections, are reported. Furthermore in cases of viral encephalitis Ara-AMP was successful. Controlled studies of a greater number of patients on the therapeutic value of Ara-AMP in infections with DNS-viruses are needed.

[Correlation of the cytochemical classification of acute leukemia in children with the course of their disease (author's transl)]. / Zur Korrelation der zytochemischen Klassifizierung akuter kindlicher Leukämien mit deren klinischem Verlauf.

Acute leukemia in 93 children was cytochemically classified into three groups: 1. the PAS-Typ (acute undifferenciated leukemia) paramyeloblastic leukemia, 2. the AML, and 3. the Acid Phosphatase Typ (SP-Typ). Therapy for the first group differed from that for AML. The acid-Phosphatase-Typ was found in only a few cases, where the acid Phosphatase is good to see in the paranuclear region of the cell. These cases have a bad prognosis. It is proposed to publish even single cases of the acid Phosphatasetype leukemia in order to find the optimal therapy.