1.
J Org Chem
; 82(14): 7648-7656, 2017 07 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28665125
RESUMO
An efficient construction of phenyl-substituted coumarin-pyrrole-isoquinoline-fused pentacycle via base-promoted Grob-type coupling of 3-nitrocoumarin and papaverine in a sealed tube is reported. This reaction is further applied to the total synthesis of lamellarin H in three linear steps and lamellarin D in eight linear steps with overall yields of 31% and 14%, respectively.