[Hemodynamics and cell membrane effects of angiotensin II receptor antagonists in treatment of hypertension]. / Gemodinamicheskie i membrannokletochnye éffekty antagonistov retseptorov k angiotenzinu II pri lechenii gipertonicheskoi bolezni.

Strain on calcium-dependent mechanisms in essential hypertension (EH) is in activation of the calcium pump, structural-and-functional changes in Ca2+ ATPase and activation of proteinase C. In EH patients presenting with a high sensitivity to angiotensin II, there comes to be frequently seen an insufficient effectiveness of antagonists of receptors to angiotensin II.

[Prognostic significance of factors of membrane pathology in hypertension]. / Prognosticheskoe znachenie disbalansa membrannykh faktorov pri gipertonicheskoi bolezni.

A rise in cell concentration of calcium, magnitude of its increment in response to stimulation, activity of proteinkinase C, and membrane content of actin have been shown to affect the complication rates in hypertensive disease (HD). A correlation has been established between the incidence of complications and membrane disorders in irregular intake of enalapril, its regular administration having been associated with a lower fatality rate and fewer complications in HD patients.

[The side effects of angiotensin-converting enzyme inhibitors in the treatment of arterial hypertension]. / Pobochnye deistviia ingibitorov angiotenzinprevrashchaiushchego fermenta pri lechenii arterial'noi gipertonii.

Wide use of angiotensin-converting enzyme (ACE) inhibitors in clinical settings is to a certain extent associated with a small number of side effects developing after taking the above medicines. The most prominent ill effects of ACE inhibitors include hypotension, acute renal impairement in those patients presenting with stenosis of the renal artery or manifest circulatory insufficiency, hyperpotassemia developing because of taking potassium-storing diuretics; cough, Quincke's edema, headache, syncope, orthostatic hypotension, nausea, diarrhea, skin eruption.

[Angiotensin-converting enzyme inhibitors in the treatment of arterial hypertension]. / Ingibitory angiotenzinprevrashchaiushchego fermenta v lechenii arterial'noi gipertenzii.

Angiotensin-converting enzyme (ACE) inhibitors have come into widespread use as a treatment option for patients with arterial hypertension, which fact can be explained by their apparent hypotensive effect, a small percent of side effects, protective effects on target organs, and a possibility of reversibility of essential hypertension- and symptomatic hypertensions-related changes in the cardiovascular system. There are a great many of drug preparations belonging in the group of ACE-inhibitors (capoten, enalapril, renitec (enalapril maleate), benazepril, quinapril, cilazopril, lizinopril, ramipril--to name but few of them. Specificities of different representatives of ACE-inhibitors, as to their clinical efficacy were found to be related to different pharmacokinetic properties of drugs.

[The hemodynamic, humoral and cellular effects of plasmapheresis in a refractory form of hypertension]. / Gemodinamicheskie, gumoral'nye i kletochnye éffekty plazmafereza pri refrakternoi forme gipertonicheskoi bolezni.

Plasmapheresis effects on hemodynamics, neurohumoral, immunological and cell parameters were examined in 48 patients with refractory hypertension. Hypotensive effect of plasmapheresis was found to combine with positive hemodynamics and microcirculatory shifts, pressor factor activity inhibition, slowing of immunocomplex condition progress, reduced red cell deformability in refractory hypertension.

[The role of the natriuretic hormone in neurohumoral regulation in hypertension]. / Rol' natriiureticheskogo gormona v neirogumoral'noi reguliatsii pri gipertonicheskoi bolezni.

Natriuretic hormone is a digoxin-like substance that inhibits Na-K-ATPase, membraneous sodium pump, leads to storage of sodium in the cells, increases their tone which plays a key role in the increase of peripheral resistance of the blood vessels and progression of hypertensive disease. Results indicate that the level of natriuretic hormone was increased at all stages of hypertensive disease, positively correlated with aldosterone and kallikrein and negatively--with the plasma renin activity that confirms its pressor action.