RESUMO
Studies in plasma medicine, which are currently actively expanding, are of multidisciplinary character, involving physical, chemical and biological processes. Rapid progress has been achieved in this field due to synergy between experimental and theoretical/computational methods. Joint use of diagnostic tools and computations gives a better understanding of mechanisms of interaction of plasma with bio-objects. This review focuses on recent achievements in modeling of plasma for biomedical applications. Various computational approaches used in these studies are described. We discuss some results of simulations that concern the production of reactive species by plasma and their delivery to bio-objects, and we consider the effect of electroporation at direct contact of cold plasma with cells.
Assuntos
Pesquisa Biomédica/métodos , Modelos Biológicos , Espécies Reativas de Nitrogênio/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Animais , Transporte Biológico , Pesquisa Biomédica/tendências , Eletricidade , Eletroporação/métodos , Humanos , Simulação de Dinâmica Molecular , Gases em Plasma/química , Gases em Plasma/farmacologia , Espécies Reativas de Nitrogênio/agonistas , Espécies Reativas de Oxigênio/agonistas , Staphylococcus aureus/química , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/crescimento & desenvolvimentoRESUMO
The use of gas phase plasmas for treating human tissue is at the intersection of two disciplines - plasma physics and engineering, and medicine. In this paper, a primer will be provided for the medical practitioner on the fundamentals of generating gas phase plasmas at atmospheric pressure in air for the treatment of human tissue. The mechanisms for gas phase plasmas interacting with tissue and biological fluids will also be discussed using results from computer modeling.