MANAGEMENT OF EMOTIONAL DISORDERS IN ELDERLY PATIENTS UNDERGOING SURGICAL TREATMENT OF PROXIMAL FEMORAL FRACTURES.

The goal of our research was to study the to identify key aspects of the management of emotional disorders in the practice of operative treatment of proximal femoral fractures in elderly patients. The study was conducted with 24 patients who needed surgical treatment of proximal femoral fracture and were at risk for the development of psycho-emotional disorders due to the presence of emotional disorders of an anxiety-depressive nature were examined. The presence of such disorders was recorded at the time of admission, before and after surgical treatment using specialized psychodiagnostic techniques. Mini Mental State Examination, modified Hachinski ischemic scale, Frontal assessment battery, Spielberg-Khanin Scale of Reactive and Trait Anxiety, The Zung Self-Rating Depression Scale were used. Results of the clinical study of the Most patients at risk had a high level of reactive anxiety - 14 (58.33%) patients (equally in subgroups I and II - 7 (29.17%) patients in each) compared with moderate levels (10 (41.67%) patients) - equally I and II subgroups (5 (20.83%) patients in each). In the subgroups I and II with moderate and high levels of reactive anxiety, a predominance of female patients was noted: subgroup I - female patients with a moderate level - 3 (12.50%), and with a high level -5 (20.83%); subgroup II - 3 (12.50%) and 4 (16.67%) female patients respectively. As a result of determining the key aspects of the management of emotional disorders in the practice of operative treatment of proximal femoral fractures in elderly patients:the presence of moderate (41.67%) and high (58.33%) levels of reactive and trait anxiety in elderly patients with proximal femoral fractures and emotional disorders is noted. The presence of a depressive state of varying severity was recorded: a subdepressive state (75.00%) and mild depression (25.00%). The general levels of reactive and trait anxiety and depressive disorders showed the presence of limit levels between moderate, high (reactive and trait anxiety) and mild depression and sub-depressive state (depressive disorders): reactive anxiety (42.52±0.05), trait anxiety (42.23±0.07) and depressive disorders (51.41±0.07). It is proved that the treatment of emotional disturbances of the anxiety-depressive spectrum lead to a significant levelling in existing psychological changes.The deterioration of the existing emotional disorders of the anxiety-depressive spectrum among patients at risk in the absence of drug treatment has been established.

LACTOSE TOLERANCE AND RISK OF MULTIFACTORIAL DISEASES ON THE EXAMPLE OF GASTROINTESTINAL TRACT AND BONE TISSUEPATHOLOGIES.

Metabolism changes play a key role in many mammalian diseases such as decreasing bone mineral density, osteoporosis, digestive disorders. Lactose intolerance is found in 75% of the in human world's population. The aim of this study was evaluation of the genetic aspects of lactase deficiency in different ethnic groups and its relation with pathologies of bone tissue and gastrointestinal tract. The world data of lactose tolerance, hip fracture incidence, digestive diseases were derived from websites the International Osteoporosis Foundation and World Health Organization. Statistical analysis was carried out by Shapiro-Wilk test, Spearman correlation. An analysis of the world population showed that the lactose tolerance parameters have a statistically significant positive correlation with the hip fractures frequency (r=0.656) and a negative correlation with digestion diseases mortality (r=-0.577). An important factor in the pathologies prevention is the diet correction taking into account the phenotype and genotype of lactose tolerance.

[Corticosteroid response and indolamine content of the mouse brain under the action of a pheromone, disrupting spermatogenesis]. / Kortikosteroidnyi otvet i soderzhanie indolaminov v mozge myshei pri deìstvii feromona, narushaiushchego spermatogenez.

The volatile components of adult male urine from laboratory mice of CBA/LacSto strain inhibited spermatogenesis in CBAB6F1 30-day old mice. There were no significant responses in hypothalamic and olfactory bulb indolamine systems, neither in the blood corticosterone level of the mice during experimental treatment. A prolactin mechanism of the pheromone inhibition of testicular function is suggested.