HYGIENIC ASSESSMENT OF THE PREVALENCE OF VITAMIN D DEFICIENCY STATES ASSOCIATED WITH DYSLIPIDEMIA IN THE ADULT POPULATION OF SOUTHERN UKRAINE.

Vitamin D deficiency is being challenged by the European and global pandemic. Exploring the role of other components in the system of regulation of lipid metabolism, their interrelationships with other systems, without a doubt, building a broader understanding of the pathogenesis of dyslipidemia and promoting new methods of correction and prevention. Impaired lipid metabolism may be accompanied by accumulation of inactive forms of vitamin D due to supra-excess catabolic processes, as well as enzymatic impairment due to a decrease in hydroxylase activity in the liver infiltrated with fat. Vitamin D deficiency can be considered as an independent factor in the risk of accumulation of adipose tissue due to the significant number of vitamin D receptors in the adipose tissue, and take part in lipogenesis, lipogenesis adipogenesis. In the course of the study, 928 residents of the southern region of Ukraine aged from 19 to 82 were examined. The study took place during the year, which made it possible to evaluate the fluctuations of the 25(OH)D level in different months with different duration of insolation. It was established that 33.6% of the examinees had a deficiency of 25(OH)D in blood serum, 33% had an insufficiency, and a sufficient level was noted in 33.4% of the examinees. Cultivation of level 25(OH)D was observed in fallow season. We also carried out a correlation analysis between 25(OH)D and lipid profiles in different seasons. Given data about the need for active follow-up of lipid metabolism and vitamin-D-deficiency in the population with further development and implementation of the system of prevention.

MODERN ETIOLOGICAL STRUCTURE OF ACUTE GASTROENTEROCOLITIS IN THE SOUTHERN UKRAINE.

The etiological structure of the acute diarrhoeal infections among the population of the Odessa region during 2015-2017 was analyzed. Based on the registered cases, an assessment of the frequency of hospitalization of sick persons from different age groups was undertaken. The most frequent pathogens from 18 detected bacterial causative agents were St. aureus, Kl. pneumoniae, Ps. aeruginosa, E. coli, Pr. vulgaris, Ent.cloacae. During 2016-2017 the mixed infection was detected in 54 fecal samples. Bacterial-virus associations were detected in 20 samples and were presented in St. aureus, Kl. pneumoniae, Ps. Aeruginosa and Rotavirus. During the summer period of 2016, the detection rate of rota-, noro-, adenovirus antigens in the examined fecal samples of adult patients was 13.60%. According to the results of genotyping of the circulating rotaviruses strains in 2016, strains G1P[8] (46.70%) and G3P[8] (26.70%) are most commonly detected.