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BACKGROUND: This preliminary study assesses the effects of initial periodontal treatment on salivary levels of 8-hydroxy-deoxyguanosine (8-OHdG) as a marker of oxidative stress in patients with chronic periodontitis (CP). METHODS: At baseline, clinical parameters and saliva samples were obtained from 20 patients with CP and 10 patients with clinically healthy periodontium. Saliva samples were collected, and clinical periodontal measurements were repeated at 2, 4, and 8 weeks after initial periodontal therapy in patients with CP. An enzyme-linked immunosorbent assay was used to investigate 8-OHdG levels of saliva samples. RESULTS: Statistically significant higher 8-OHdG levels of saliva and a significant decrease after initial periodontal therapy were determined in the CP group (p < 0.001). A significant positive correlation was found between 8-OHdG levels of saliva and clinical periodontal measurements (p < 0.001). CONCLUSION: Within the limits of this short-term preliminary study it can be concluded that the estimation of 8-OHdG levels in saliva may be used to evaluate the oxidative stress in periodontitis patients. It also appears that oxidative stress, which is reflected by salivary 8-OHdG levels, might reflect the present status of periodontal health.
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AIM: : The purpose of this trial was to evaluate the outcome of a modification of pin hole surgical technique which consists of a minimally invasive coronally advanced tunnel technique (MI-CAT) with orthodontic buttons and suturing in the treatment of multiple recession type defects. MATERIALS AND METHODS: Twelve systemically healthy patients (79 sites) aged between 22 - 55 years with Miller's Class I and II multiple recession defects were treated with minimally invasive coronally advanced tunnel technique. Thirty-nine sites were randomly assigned to a control group and the other 40 sites to the test group. In the test group, in addition to the MICAT procedure, buttons and suspensory silk sutures were used for the stabilization of the advanced flap. Clinical parameters were assessed at baseline, 3 weeks, 6 weeks and 6 months after surgery. RESULTS: A total of 79 recessions were treated. Complete root coverage from baseline to 6 months was 56% in the control group and 73% in the test group. Mean root coverage was 82.4% in the control group and 85.7% in the test group. Root coverage aesthetic scores of 9.3/10 and 9.4/10 were noted in the control and test group respectively. CONCLUSION: Six months post-surgical evaluation showed that minimally invasive coronally advanced tunnel technique with orthodontic buttons and suturing was effective and predictable for the treatment of multiple recession type defects. The clinical outcomes were similar to that of the control group with no statistical difference between the two groups.
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INTRODUCTION: Chitosan is a natural polymer found in abundance in nature. It has antimicrobial and anti-inflammatory properties and is biodegradable and biocompatible in nature. It has been used in various forms as an anti-microbial agent in oral care. However, to date, chitosan has not been investigated as a form of local drug delivery (LDD)in the management of non-surgical periodontal treatment (NSPT). Therefore, we aim to investigate the efficacy of natural 1% (w/w) resorbable chitosan membrane as an adjunct to scaling and root planing (SRP) in non-surgical management of chronic periodontitis. MATERIALS AND METHODS: Ten patients with pocket probing depth (PPD) of ≥ 5 mm were categorized randomly into two treatment groups: test group (SRP plus 1% chitosan membrane) and control group (SRP), in a split-mouth study. The clinical parameters recorded were pocket probing depth (PPD), gingival index (GI) and bleeding on probing (BOP) at baseline before SRP and after 4 weeks. Statistical analysis was performed using Student's t-test, Pearson's chi-squared test, the Wilcoxon signed rank test and the Mann-Whitney U test; statistical significance was set at a p value ≤ 0.05. RESULTS: The test group showed significant improvement in all clinical parameters as compared to the control group. The mean difference between the outcomes of the test and the control groups for PPD was 1.4 mm. Mean ± standard deviation (SD) for GI was 0.20 ± 0.42 at 4 weeks in the test group. All sites (100%) showed a score of '0' for BOP in the test group at 4 weeks. The results were statistically significant. CONCLUSION: Within the limitations of this study, it can be concluded that chitosan membranes as a form of LDD could be used as an adjunct to NSPT.
