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2.
Clin Appl Thromb Hemost ; 17(1): 39-45, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21078609

RESUMO

BACKGROUND: The use of bovine thrombin has been an effective approach to aiding hemostasis during surgery for over 60 years. Its use has a reported association with the development of antibodies to coagulation factors with limited evidence to the clinical significance. METHODS: The Collaborative Delphi survey methodology was used to develop a consensus on specified topic areas from a panel of 12 surgeons/scientists who have had experience with topical thrombins; it consisted of 2 rounds of a Web-based survey and a final live discussion. RESULTS: Some key issues that reached consensus included: bovine, human plasma-derived and recombinant human thrombin are equally effective hemostatic agents with similar adverse event rates, and immunogenicity to a topical protein rarely translate into adverse events. CONCLUSIONS: Although a risk of immunogenicity is associated with all topical thrombins, no conclusive clinical evidence is available that these antibodies have any significant effect on short- and long-term clinical consequences.


Assuntos
Autoanticorpos/imunologia , Hemostasia/efeitos dos fármacos , Trombina/efeitos adversos , Trombina/imunologia , Trombina/uso terapêutico , Administração Tópica , Animais , Bovinos , Consenso , Coleta de Dados , Feminino , Humanos , Masculino , Procedimentos Cirúrgicos Operatórios
3.
Cardiol Rev ; 13(6): 304-8, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16230888

RESUMO

Analysis of 10 adult patients treated from January 1998 to November 2004 for arterial misplacement of triple-lumen catheter (TLC) during internal jugular vein cannulation was performed. Three cases that developed neurologic symptoms occurring in the context of infusion through a TLC that was arterially malpositioned are presented, along with the review of literature. In 7 patients, the diagnosis of arterial misplacement was suspected by the color or flow characteristics of blood and confirmed by a combination of blood gas analysis, connecting catheter to transducer, and/or chest film. In the remaining 3 patients, intraarterial misplacement was not suspected. In these patients, the initial review of chest films by qualified physicians prior to starting infusion failed to detect malposition of the catheter. Retrospectively, subtle clues suggestive of arterially placed TLCs were found. All 3 patients developed neurologic symptoms. Initiation of neurologic workup delayed a correct diagnosis by 6 to >48 hours. A volumetric pump was used for infusion in all patients. Of the 3 patients with neurologic symptoms, 1 recovered completely, 1 became comatose, and 1 partially improved. Based on our observations and review of literature, we conclude that cursory examination of chest films to verify proper positioning of central venous catheter attempted through the internal jugular vein may fail to detect arterial malposition. Infusion by volumetric pump precludes backflow of blood in the intravenous tubing as an indicator. Neurologic symptoms concurrent with the infusion of fluids and medication should raise suspicion of accidental arterial infusion.


Assuntos
Antineoplásicos/administração & dosagem , Cateterismo Venoso Central/efeitos adversos , Cateteres de Demora/efeitos adversos , Transtornos Cerebrovasculares/etiologia , Adulto , Transtornos Cerebrovasculares/diagnóstico por imagem , Feminino , Humanos , Infusões Intra-Arteriais/efeitos adversos , Veias Jugulares , Masculino , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Retais/diagnóstico por imagem , Neoplasias Retais/tratamento farmacológico , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
4.
J Am Coll Surg ; 198(6): 939-44, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15194076

RESUMO

BACKGROUND: Accidental placement of a large sheath or catheter in an artery during central venous cannulation, though rare, is a potentially devastating complication. The present study reviews our 14-year experience with this complication to determine appropriate role of surgical management. STUDY DESIGN: Review was conducted of all cases involving patients treated by the vascular surgery service from July 1989 to June 2003 for accidental placement of a large-caliber cannula (>or= 7 F) in an artery during catheterization of the jugular vein. Two management techniques were used during this period: removal of cannula followed by application of local pressure; and surgical exploration, removal of cannula under direct vision, and repair of artery. RESULTS: Eleven patients (5 men, 6 women) aged 35 to 73 years (mean age 56 years) were treated for cannulas placed accidentally in an artery. In nine patients, the cannula entered the carotid artery, and in two patients it entered the subclavian artery. Three patients had undergone placement of 8.5-F sheaths for monitoring cardiac hemodynamics, and 8 patients had triple-lumen catheters for fluid infusion or parenteral nutrition. Eight patients (three sheath, five catheter) were asymptomatic at the time of cannula removal. In three patients, the correct diagnosis was missed initially and infusion was started. All three developed neurologic symptoms. In two patients, the cannula (sheath) was pulled and pressure applied. One of them developed a stroke and the other developed a pseudoaneurysm that was treated surgically. Nine patients in whom the sheath or catheter was removed by surgical exploration had no new complications related to surgery. CONCLUSIONS: Surgical management seems to be the most effective and safe treatment of arterial misplacement of cannulas during jugular vein catheterization. Further study is needed to determine the optimum management of this potentially devastating complication.


Assuntos
Artérias Carótidas , Cateterismo Venoso Central/efeitos adversos , Cateterismo Venoso Central/instrumentação , Artéria Subclávia , Lesões das Artérias Carótidas/cirurgia , Remoção de Dispositivo , Feminino , Humanos , Veias Jugulares , Masculino , Pessoa de Meia-Idade , Pressão , Punções , Estudos Retrospectivos , Artéria Subclávia/lesões
5.
J Vasc Surg ; 36(4): 708-12, 2002 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12368730

RESUMO

PURPOSE: A review of popliteal-crural bypasses via the posterior approach was done to evaluate the results of this technique. METHODS: During a period of 36 months, 21 patients with limb-threatening ischemia underwent 21 popliteal-crural bypasses via the posterior approach in the prone position with reversed lesser saphenous vein. All patients had limb-threatening ischemia, with rest pain in five patients, ulceration in nine patients, and gangrene in seven patients. Diabetes mellitus was present in 17 patients. RESULTS: The inflow site was the supragenicular popliteal artery in 12 patients and the infragenicular popliteal artery in nine patients. The outflow sites were the tibioperoneal trunk in five patients, the posterior tibial artery in six patients, the peroneal artery in eight patients, and the anterior tibial artery in two patients. Of the seven patients with gangrene, three patients underwent transmetatarsal amputation and four underwent toe amputation. The limb salvage rate for the entire group was 100% at 24 months. No early graft failures were seen, and the 12-month and 24-month primary graft patency rates were 89% and 77%, respectively, with life-table analysis. The primary assisted patency rate was 95% at 12 and 24 months. Patency was determined with duplex scan graft surveillance. CONCLUSION: The posterior approach to popliteal-distal bypass is an acceptable alternative to traditional bypass procedure with excellent early patency and limb salvage results. The approach has the advantage of better utilization of lesser saphenous vein and easier operative exposure in patients with short segment infrapopliteal occlusive disease.


Assuntos
Arteriopatias Oclusivas/cirurgia , Anastomose Arteriovenosa , Isquemia/cirurgia , Perna (Membro)/irrigação sanguínea , Perna (Membro)/cirurgia , Salvamento de Membro , Artéria Poplítea/cirurgia , Veia Safena/cirurgia , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento
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