RESUMO
To evaluate diagnostic improvement achieved with the determination of antibody to hepatitis core antigen of IgM type (anti-HBc-IgM) and antibody to delta antigen (anti-HD) in acute type B hepatitis, 155 patients (of whom 100 were drug addicts) were studied, using these markers in association with the classical markers of viral hepatitis (anti-HBc, anti-HBs, anti-HAV-IgM and anti-cytomegalovirus antibodies). With classical diagnostic criteria, 121 patients would have been diagnosed as having B hepatitis (HBs Ag and/or anti-HBc antibody positive without anti-HBs antibody), 33 non A non-B hepatitis (all markers negative or anti-HBc and anti-HBs positive) and 3 A hepatitis (anti-HAV-IgM antibody positive). With the current markers, 89 were B hepatitis (anti-HBc-IgM antibody positive), 18 were simultaneous B and D infections (anti-HBc-IgM and anti-HD antibodies positive), 6 were D hepatitis (anti-HBc-IgM antibody negative and anti-HD antibody positive), 39 non-A non-B hepatitis (anti-HBc-IgM, anti-HD, HAV-IgM and anti-cytomegalovirus antibodies negative) and 3 hepatitis A. Of the 121 cases initially diagnosed as B hepatitis, only 79 were actually B hepatitis, 16 were simultaneous B and D infections, 6 D hepatitis, 18 non-A non-B hepatitis and 2 A hepatitis. Of the 33 cases considered to be non A non-B hepatitis, only 21 were really non-A non-B hepatitis; 10 were B hepatitis and 2 B and D hepatitis. When anti-HBc-IgM and anti-HD antibodies were determined, the initial diagnosis was modified in 54 of 155 cases (35 p. 100).(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Anticorpos Anti-Hepatite B/análise , Vírus Delta da Hepatite/imunologia , Hepatite Viral Humana/etiologia , Imunoglobulina M/análise , Doença Aguda , Adolescente , Adulto , Idoso , Criança , Feminino , Antígenos da Hepatite B/imunologia , Antígenos do Núcleo do Vírus da Hepatite B/imunologia , Antígenos da Hepatite delta , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Pneumonia/microbiologia , Adolescente , Adulto , Idoso , Infecções Bacterianas/epidemiologia , Infecções Bacterianas/microbiologia , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonia/epidemiologia , Pneumonia por Mycoplasma/epidemiologia , Pneumonia Viral/epidemiologia , Estudos Prospectivos , EspanhaAssuntos
Anticorpos Antinucleares/análise , Sítios de Ligação de Anticorpos , Proteínas do Sistema Complemento/imunologia , DNA/imunologia , Lúpus Eritematoso Sistêmico/imunologia , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Fragmentos Fc das Imunoglobulinas/imunologia , Nefropatias/etiologia , Lúpus Eritematoso Sistêmico/complicações , Masculino , Pessoa de Meia-IdadeRESUMO
Eighty-two patients with systemic lupus erythematosus (SLE) were investigated for the presence and significance of serum antibodies to Extractable Nuclear Antigen (ENA) and its major components, RNP, Sm and SS-B (or Ha). The counterimmunoelectrophoresis assay allowed independent detection and measurement of antibodies to the different components. Forty patients had anti-ENA antibodies, 25 (30%) were of anti-RNP type alone or anti-RNP associated with anti-Sm, and 12 (15%) were of anti-RNP type alone. Anti-ENA antibodies distinguished a subset of patients with less common incidence of renal disease, positive Coombs test, anticoagulant serum factors and high titres of anti-DNAds antibodies, with higher incidence of Raynaud's phenomenon, swollen hands, hypergammaglobulinemia and high titres of antinuclear antibodies with speckled pattern on immunofluorescence. SLE patients with anti-RNP antibodies had in addition a high frequency of normal complement values. All but one SLE patient with only anti-RNP antibodies fulfilled at least four or more criteria for the diagnosis of SLE. We conclude that anti-ENA antibodies in SLE patients are associated with a low prevalence of nephritis and a clinical and laboratory profile similar to that of the MCTD syndrome. These findings demonstrate the difficulty of inferring rigid differences between MCTD and SLE. The MCTD syndrome probably represents only one segment of the whole clinical spectrum of SLE.
Assuntos
Anticorpos Antinucleares/análise , Lúpus Eritematoso Sistêmico/imunologia , Nucleoproteínas/imunologia , Antígenos Nucleares , Contraimunoeletroforese , HumanosRESUMO
Angiofollicular lymph node hyperplasia is a disease of unknown etiology in which two distinct histologic forms are recognized: the hyalin vascular and the plasma-cell types. Up to the current time only a few multicentric cases have been described. The authors describe an unusual case of the multicentric type, which furthermore showed an excellent response to low dosis radiotherapy. Complete, lasting remission was induced and the patient became asymptomatic.
Assuntos
Hiperplasia/radioterapia , Linfonodos/patologia , Idoso , Humanos , Hiperplasia/patologia , MasculinoAssuntos
Antígenos do Núcleo do Vírus da Hepatite B/imunologia , Antígenos de Superfície da Hepatite B/imunologia , Vírus da Hepatite B/imunologia , Hepatite B/imunologia , Imunidade Materno-Adquirida , Adolescente , Adulto , Feminino , Feto/imunologia , Humanos , Recém-Nascido , Gravidez , Complicações Infecciosas na Gravidez/imunologiaAssuntos
Abscesso Encefálico/complicações , Homossexualidade , Sarcoma de Kaposi/complicações , Toxoplasmose/complicações , Adulto , Encéfalo/ultraestrutura , Abscesso Encefálico/etiologia , Abscesso Encefálico/parasitologia , Humanos , Masculino , Sarcoma de Kaposi/imunologia , Sarcoma de Kaposi/patologia , Toxoplasma/isolamento & purificaçãoRESUMO
A 33-year-old man had had, since he was 20 years old, recurrent attacks of fever, rash, and aseptic lymphocytic meningitis. A nephrotic syndrome developed that was found, on renal biopsy, to be due to amyloid deposit. After colchicine therapy, no further recurrence of fever and meningitis was observed. These findings suggest that aseptic periodic meningitis (Mollaret's syndrome) should be considered as an unusual manifestation of familial Mediterranean fever.