RESUMO
BACKGROUND: The chemical-mechanical removal of caries involves the chemical softening of the infected dentin, following by the mechanical removal of the softened tissue using non-cutting manual instruments. Papacárie (Fórmula&Açao, Sao Paulo, Brazil) is a product in gel form used for the chemical-mechanical softening of the affected tissue. OBJECTIVE: The purpose of the present study was to evaluate the effectiveness of Papacárie. METHODS: Clinical and radiographic evaluations were performed on 14 young permanent molars treated with Papacárie and restored with glass ionomer cement (VitroMolar DFL Ind. Com LTDA, Rio de Janeiro, Brazil) 24 months following intervention. RESULTS: Success was achieved in 13 of the 14 cases. CONCLUSION: Papacárie was effective in the treatment of carious lesions and constitutes a conservative alternative that offers benefits to patients.
Assuntos
Tratamento Dentário Restaurador sem Trauma/métodos , Cárie Dentária/terapia , Preparo da Cavidade Dentária/métodos , Cimentos de Ionômeros de Vidro/uso terapêutico , Papaína/uso terapêutico , Adolescente , Criança , Cárie Dentária/diagnóstico por imagem , Falha de Restauração Dentária , Restauração Dentária Permanente/métodos , Seguimentos , Géis , Humanos , Dente Molar/diagnóstico por imagem , Estudos Prospectivos , Radiografia , Resultado do TratamentoRESUMO
Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced in adult marmosets by pilocarpine injection (250mg/kg; i.p.). The animals were divided in 2 groups: acute (8h post-SE) and chronic (3 and 5 months post-SE). To manage the severity of SE, animals received diazepam 5min after the SE onset (acute group: 2.5 or 1.25mg/kg; i.p.; chronic group/; 1.25mg/kg; i.p). All animals were monitored by video and electrocorticography to assess SE and subsequent spontaneous recurrent seizures (SRS). To evaluate brain injury produced by SE or SRS we used argyrophil III, Nissl and neo-Timm staining techniques. Magnetic resonance image was also performed in the chronic group. We observed that pilocarpine was able to induce SE followed by SRS after a variable period of time. Prolonged SE episodes were associated with brain damage, mostly confined to the hippocampus and limbic structures. Similar to human TLE, anatomical disruption of dentate gyrus was observed after SRS. Our data suggest that pilocarpine marmoset model of epilepsy has great resemblance to human TLE, and could provide new tools to further evaluate the subtle changes associated with human epilepsy.
