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1.
Clin Trials ; 14(1): 103-108, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27488223

RESUMO

BACKGROUND: Successful recruitment in clinical trials for chronic pain conditions is challenging, especially in women with provoked vulvodynia due to reluctance in discussing pain associated with sexual intercourse. The most successful recruitment methods and the characteristics of women reached with these methods are unknown. OBJECTIVE: To compare the effectiveness and efficiency of four recruitment methods and to determine socioeconomic predictors for successful enrollment in a National Institutes of Health-sponsored multicenter clinical trial evaluating a gabapentin intervention in women with provoked vulvodynia. METHODS: Recruitment methods utilized mass mailing, media, clinician referrals and community outreach. Effectiveness (number of participants enrolled) and efficiency (proportion screened who enrolled) were determined. Socioeconomic variables including race, educational level, annual household income, relationship status, age, menopausal status and employment status were also evaluated regarding which recruitment strategies were best at targeting specific cohorts. RESULTS: Of 868 potential study participants, 219 were enrolled. The most effective recruitment method in enrolling participants was mass mailing ( p < 0.001). There were no statistically significant differences in efficiency between recruitment methods ( p = 0.11). Relative to clinician referral, black women were 13 times as likely to be enrolled through mass mailing (adjusted odds ratio 12.5, 95% confidence interval, 3.6-43.1) as white women. There were no differences in enrollment according to educational level, annual income, relationship status, age, menopausal status, or employment status and recruitment method. CONCLUSION: In this clinical trial, mass mailing was the most effective recruitment method. Race of participants enrolled in a provoked vulvodynia trial was related to the recruitment method.


Assuntos
Aminas/uso terapêutico , Analgésicos/uso terapêutico , Ensaios Clínicos como Assunto , Ácidos Cicloexanocarboxílicos/uso terapêutico , Seleção de Pacientes , Vulvodinia/tratamento farmacológico , Ácido gama-Aminobutírico/uso terapêutico , Adulto , Negro ou Afro-Americano , Fatores Etários , Relações Comunidade-Instituição , Escolaridade , Etnicidade , Feminino , Gabapentina , Humanos , Renda , Estado Civil , Meios de Comunicação de Massa , Pessoa de Meia-Idade , Serviços Postais , Grupos Raciais , Fatores Socioeconômicos , População Branca
2.
J Womens Health (Larchmt) ; 24(10): 831-6, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26291682

RESUMO

BACKGROUND: The prevalence of vulvodynia has been reported to be lower in black compared to white and Latina women. Use of different terminology to describe vulvar pain symptoms may play a role in lower prevalence. The objectives were to compare pain descriptors used by black and white women with provoked vulvodynia (PVD) to determine the effect of race on symptom reporting. METHODS: Ninety-two women, self-identified as black (n = 55) and white (n = 37) with clinically confirmed PVD completed a questionnaire containing demographic information and vulvar pain characteristics. Variables that were significant with race retained in the logistic regression model were included in multivariate analysis to determine the effect of race on reporting of vulvar pain symptoms. RESULTS: Of statistical significance, white women more often described their pain as burning as compared with black women (84% vs. 22%, p ≤ 0.0001). White women more frequently reported their pain as stinging (51% vs. 29%, p = 0.03) and itching (32% vs. 15%, p = 0.04) as well, whereas there was a trend for black women to more often describe their pain as aching (67% vs. 49%, p = 0.07). Overall, white women were 19 times as likely to report their pain as burning (adjusted odds ratio [aOR] 18.51, 99% confidence interval [CI] 4.46-76.86). CONCLUSIONS: These data suggest that black women are less likely to self-report their vulvar pain as burning, the classic symptom of PVD. Cultural influences and different underlying pain mechanisms may contribute to differences in symptom reporting by race.


Assuntos
População Negra , Vulvodinia/etnologia , Vulvodinia/patologia , População Branca , Adulto , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Medição da Dor , Dor Pélvica , Autorrelato , Estados Unidos/etnologia , Adulto Jovem
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