Altruism versus self-centredness in the personality of depressives in the 1950s and 1990s.

BACKGROUND: Research in personality features of patients with major depression has emphasised their tendency to set high standards for themselves. Two directions of acting on high standards have been differentiated which can be summarised as altruistic and self-centred attitudes. Typus melancholicus and narcissistic personality features are representative for them. Since both types of features are age correlated, the question had to be settled whether this reflects an individual process of social adaptation or an epochal change of values. METHODS: The study is based on a representative sample of case records of first episode depressives. Two cohorts of the 1950s and two of the 1990s were sampled. In both decades, one cohorts' age of onset was below 40 whereas the other cohorts' age of onset was over 40. Each cohort comprised 20 patients, yielding a total sample of 81 patients. The information from the records was prepared and evaluated in a two step procedure according to v. Zerssen. RESULTS: Increase of altruism and decrease of self-centredness with advancing age could be confirmed. There is a weak to moderate epochal decline of altruistic attitudes only in the older cohorts and a marked increase of self-centred attitudes in both, the young and the old cohorts. LIMITATIONS: The assessment of depression diagnosis and personality types by means of case records in a retrospective design could limit the reliability and validity of the measured concepts. In addition, items regarding narcissistic features were not validated in other samples. CONCLUSION: Both, the age effect and the epochal effect show that such aspects should be born in mind for the psychotherapeutic treatment of depressive patients. This is especially important since basic personality attitudes contribute to the etiology of depression, partly conveyed by societal values, partly by requirements of life-spans in the individual life history.

Prevalence, onset and comorbidity of postpartum anxiety and depressive disorders.

OBJECTIVE: The study presents data on the 3-month prevalences of postpartum anxiety disorders (PAD) and postpartum depressive disorders (PDD) and their comorbidity in a German community sample. Associations with sociodemographic variables and previous history of psychopathology were analysed. METHOD: Data were gathered in a longitudinal study over the first 3 months postpartum. In a two-stage screening procedure, a population-based representative sample of 1024 postpartum women was assessed for symptoms of anxiety and depression using DSM-IV-based screening instruments. RESULTS: The estimated rates of DSM-IV disorders were 11.1% for PAD and 6.1% for PDD. Comorbidity was found in 2.1%. The rate for PAD with postpartum onset was 2.2% and for PDD 4.6%. Young mothers and mothers with a low education level had a heightened risk of developing depression following delivery. CONCLUSION: Because of the clinical relevance of PAD, controlled studies and specialized programmes for prevention and treatment are urgently required.

The German version of the Postpartum Bonding Instrument: psychometric properties and association with postpartum depression.

BACKGROUND: To date there has been no study investigating mother-infant bonding impairment and its link to pospartum depressive symptoms in a representative German population sample. The present study therefore aimed to carry out initial analyses of the psychometric properties of the German version of the Postpartum Bonding Questionnaire (PBQ). METHODS: Eight hundred and sixty two mothers provided the data for a principal component analysis of the original 25 item PBQ. This analysis was used to assess the validity of the four scale structure of the questionnaire. Correlations between postpartum depression, sociodemographic variables and bonding impairment were additionally calculated. FINDINGS: On the basis of our data, the original 4 factor structure of the PBQ scale was not confirmed. Nine items did not meaningfully load onto the single factor accounting for the most variance. Mother-infant bonding impairment and postpartum depression were shown to be significantly positively correlated. According to the factor solution of Brockington we found a 7.1% rate of mothers with bonding impairment two weeks postpartum (with 95% confidence ranging from 5.5 to 9%). INTERPRETATION: An abridged 16 item German version of the PBQ can be implemented as a reliable screening instrument for bonding impairment.

[Treatment utilisation of a psychoeducational group for relatives of patients with affective disorders]. / Inanspruchnahme eines psychoedukativen Gruppenangebotes für Angehörige von Patienten mit affektiven Störungen.

The relevance of family interactions in the course of affective disorders has been well described. In contrast to the situation regarding schizophrenic disorders, there are few systematic concepts for involvement of the relatives of patients with affective disorders in treatment. The goal of this study was the development and evaluation of a standardised psychoeducational treatment programme. We determined the number and characteristics of relatives accepting the offer of such a group. Relatives of almost half of 55 patients with major depression and a bipolar disorder participated in the group. Relatives of male patients were more likely to take part than relatives of female patients. Relatives of patients with a bipolar disorder were more likely to take part than relatives of patients with unipolar depression. The patients whose relatives attended the group showed a more favourable understanding of the illness and more knowledge about affective disorders, but on the other hand, felt themselves to be more strongly criticised by their relatives and had less social support than the other patients. These results emphasise the importance of differential family-focused treatment modalities in affective disorders.

[Effect of personality factors and structure on the course of major depression]. / Einfluss von Persönlichkeitsfaktoren und -struktur auf den Verlauf der Major-Depression.

The extent to which personality characteristics predict the course of severe depression has been controversially discussed. In a sample of 50 depressed inpatients, the significance of personality characteristics for the prediction of relapse was studied prospectively over 2 years. More than half of the patients studied suffered relapses within this period. Well-known predictors such as the number of previous episodes were confirmed. The personality characteristics studied showed different predictive effects at 1- and 2-year follow-up. Neurosis proved predictive of the 1-year course and outcome but not the 2-year course. In the 2nd year of follow-up, a melancholic personality structure was associated with favourable outcome. This personality type therefore seems to be more appropriate as a predictor of long-term outcome. Comparison with predictive factors described earlier showed that in this study, personality traits influence outcome independently and were not confused by other predictors. Implications for relapse prevention and psychotherapeutic management are discussed.

[Prospects in psychotherapy research]. / Perspektiven der Psychotherapieforschung.

The point of departure for this discussion is a critical review of the philosophy of randomized controlled trials (RCT) and their specific errors when applied to psychotherapeutic methods. There is a gap between the highly artificial settings of psychotherapy RCT and naturalistic psychotherapy procedures, which are grounded more in personality than in technique, less regulated, and mostly eclectic. Although RCT are necessary for general assessments of efficacy, they should be complemented by efficiency studies and evaluation of whole health care systems which include psychotherapy. We argue against overstretching the analogy of good clinical practice (GCP) research for the purpose of admitting new psychotropic drugs to psychotherapy research. A rational approach to psychotherapy for indication, quality ascertainment, and allocation of resources needs research which is methodologically explicable, replicable, and relevant to practice. The Cochrane Collaboration is a means of distributing such knowledge and making it work for practitioners. However, Cochrane also sheds light on psychological and practical obstacles which must be overcome before public health care systems can utilize new scientific results. The discussion of disorder-specific psychotherapy versus general psychotherapy ends by emphasizing the importance of more detailed psychopathology and pathopsychology of dysfunctions that cannot be sufficiently explained in manuals. Such dysfunctions--not necessarily specific for diagnoses or abnormality at all--can then be matched to specific psychotherapy tools. Further innovations can be expected from neurosciences, and some of the most promising paradigms are discussed. Finally, the lasting importance of hermeneutics is stressed not only with regard to the generation of new hypotheses but also to guiding the psychotherapeutic process.

Reconfirming the role of life events for the timing of depressive episodes. A two-year prospective follow-up study.

BACKGROUND: Since the 1960s the association of stressful life events and depression seemed to be firmly established. However, a few recent studies did not confirm those earlier findings. One of the reasons discussed for the inconsistencies was the sampling of milder depressed neurotic out-patients in the earlier studies vs. more severely ill endogenous type in-patients in recent studies. METHODS: This investigation was carried out with 50 consecutively admitted in-patients with endogenous depression according to ICD 9 and unipolar major depression according to DSM-III-R as ascertained by SCID. The control sample consisted of 26 healthy volunteers. Life events and chronic distressing life conditions were recorded with the Munich Interview for the Assessment of Life Events and Conditions (MEL) every 3 months over a period of 2 years along with psychopathological symptoms and recurrencies. Hence the design was prospective in the sense that life events were recorded for one 3-month cross-section, the depressive reaction for the subsequent one. BDI scores taken at the respective cross section were used to control for depressive bias of the subjective part of the patient's life event evaluation. RESULTS: Three months prior to the index hospitalization patients were more often affected by life events and conditions than controls. The number of stressful conditions prior to the index hospitalization indicated the time to relapse after discharge. Controls showed more desirable positive conditions than patients. Relapse patients suffered more often stressful life events and conditions than non-relapsers 3 months prior to their relapse. Multivariate analysis indicates that the cumulative number of life events within the 2-year course is the best predictor of the BDI score at the end of the follow-up period. LIMITATIONS: Since the subjective component of life event assessment by MEL displayed a higher impact on the course of depression than the objective part of the assessment, confounding of subjective ratings, attributional styles, and depressive symptoms may be a problem although controlled for in this study. CONCLUSION: The results support the importance of stressful life events and chronic distressing conditions for the 2-year course and outcome of major depression in an in-patient sample. Since the overall consistency of significant results was more pronounced in the subjective than in the objective part of the MEL the results fit best a circular pathogenetic model of interactions between life events, their individual evaluation by the patient, and depressive symptoms.

[Critical life events during the course of 2 years of 'major depression.' A prospective study with inpatients]. / Kritische Lebensereignisse im 2-Jahresverlauf der "Major Depression." Eine prospektive Studie mit stationär behandelten Patienten.

A number of studies has shown a significant relationship between life events/life conditions and depression. However, there is only a small number of studies investigating the effect of life events/life conditions in patients with severe depression from the endogenous subtype. The results are inconsistent. The present study examines the significance of the patients' life events/life conditions for the two year outcome of the illness in a prospective study with assessments every three months. Patients are compared to healthy controls with regard to the period three months prior to the admission to the hospital at the index episode. The results confirm the importance of life events and life conditions for the long term outcome of depressed patients with endogenous subtype respectively severe major depression in-patients. Relapsers show considerably more undesirable life conditions than non-relapsers three to six months prior to their relapse. Depressed patients indicate significantly more undesirable life events and life conditions and fewer desirable life conditions in comparison to the control group for the time span three months prior to their hospitalization. Clinical implications are discussed.

Sampling biases in a marital study on severe major depression.

A comparison was carried out between participants and refusers to participate in a 2-year prospective follow-up study of major depression. 88 consecutively admitted patients of the Psychiatric University Hospital Heidelberg had been addressed. All of them fulfilled both the ICD-9 criteria for Endogenous Depression and the DSM-III-R criteria for Major Depression according to SCID. 38 patients declined participation. Participants and refusers were compared with regard to 56 items of psychopathological symptomatology, socio-demographic data, quality of marital relationship, and personality features. The information about these items was taken systematically from the medical records both of participants and refusers. For some items methods of content analysis were applied to the case histories. Only few differences between participants and refusers were found. Women and more severely ill patients were less willing to accept participation. The degree of marital problems did not differentiate between consenters and refusers.

["Expressed emotion", marital quality and risk of recurrence in depressed patients]. / "Expressed Emotion" (EE), Ehequalität und das Rückfallrisiko depressiver Patienten.

Long-term course of depression appears to be clearly correlated to marital quality and quality of the relationship with spouses. Aim of the present study is the replication of results, indicating that expressed emotion (EE) is an important factor in prediction of relapse in depression. Additionally, the correlation between EE shown by spouses and the severeness of depressive symptomatology as well as the importance of martial quality as seen by patients for relapse are investigated. Results of our study indicate that spouses EE does not predict relapse, and status of EE does not correlate with the extent of depressive symptoms. However, patient self ratings of satisfaction with marital relationship and of perceived criticism are related to relapse frequency. Additionally, discrepant ratings of marital satisfaction given by spouses predict relapse to some extent. Implications for research in affective disorders and clinical practice are discussed.

The influence of psychopathology, personality, and marital interaction on the short-term course of major depression.

By means of an aggregated variables design the domains of 'psychopathology', 'personality', and 'social interaction' were weighted according to their impact on the 2-year course of 50 patients with unipolar major depression. Preindex course ranked highest, asthenic personality second. Variables of social interaction disappeared in the second-order logistic regression. These findings fit in well with the recent literature. They are interpreted in terms of habituation processes and residual personality changes which lower the vulnerability threshold for relapse and unfavorable course. As a consequence of this conclusion early relapse prevention would be most important.

[Utilization of ambulatory psychotherapy by patients with endogenous depression after inpatient psychiatric treatment]. / Inanspruchnahme ambulanter Psychotherapie von Patienten mit endogener Depression nach stationär-psychiatrischer Behandlung.

The long-term course of major depressive disorder is often accompanied by relapses or chronicity. Since psychosocial factors have been shown to be important predictors for the long-term outcome, psychotherapy along with drug therapy belongs to the standard methods of treatment. In spite of the effectiveness of psychotherapy, only some of the inpatients are treated with outpatient psychotherapy after hospital discharge. Within the framework of the Heidelberg depression study the authors examined what kind of, how many and for how long endogenously depressed patients sought out-patient psychotherapy after an inpatient treatment in a two-year follow-up. During the follow-up one half of patients were treated with outpatient psychotherapy. They were found to be younger, had suffered from more previous episodes, and their personality was more disturbed than those who had not undergone psychotherapy. The Expressed Emotion index did not make any further difference, whereas certain aspects of partnership quality did. The distinction between the two groups of patients is discussed regarding possible selection processes by treatment indication. It is pointed out that research on synergistic cooperation between members of the mental health services is highly desirable.

Personality and endogenous/major depression: an empirical approach to typus melancholicus. 2. Validation of typus melancholicus core-properties by personality inventory scales.

The purpose of this study was to objectify some of the personality dimensions of the typus melancholicus (TM) personality formation in endogenous depressives and to compare the consistency of the term used in questionnaires with the original concept as delineated in our preceding paper. The prevalence of TM in endogenous-depressive inpatients was 51% for patients with clearly salient TM features. In addition 25% of the sample showed TM features to a minor extent. These findings are consistent with the literature. MMPI and MPI could not separate TM and non-typus melancholicus (NTM) in univariate analyses. However, the Munich Personality Test (MPT) contributes to validating the TM concept. TM depressives scored significantly higher in MPT subscales rigidity and norm orientation. According to its item structure the MPT rigidity subscore can be considered to conceptually encompass hypernomia, i.e. the patient's incapacity to change the norms that were once adopted. Based on the characteristics of item formulations in the MPT subscore norm orientation it was hypothesized that this subscore corresponds to the concept of heteronomia, i.e. conformism towards externally determined and uncritically followed social norms. Since MPT norm orientation in TM does not covariate with control scales of the other inventories used in this study, it is likely that MPT norm orientation refers to the TM patient's sincere commitment to social norms rather than to a sham reaction in the sense of a lie scale. There was no consistent indication that TM shows lower neuroticism scores than NTM.

Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia.

Quantitative magnetic resonance imaging (MRI) was used to investigate volumes of different brain structures in 19 patients with late-onset major depression (DSM-III-R), 27 patients with Alzheimer's disease (NINCDS-ADRDA criteria) and 13 age matched controls. 3-D MRI sequences were acquired using a Siemens 1.5 T scanner. Whole brain volume, CSF volume, volume of the frontal and temporal lobes and the volume of the amygdala-hippocampus complex were assessed using the software NMR Win. Compared to the controls, depressed patients showed a significantly lower whole brain volume and a significantly higher CSF volume, whereas volumes of the frontal and temporal lobes as well as the amygdala-hippocampus complex volumes were not significantly decreased. In addition, depressed patients exhibited a higher ventricle-brain ratio suggesting a higher degree of central atrophy compared to healthy individuals. In contrast, Alzheimer patients showed significantly lower volumes than depressed patients and controls with respect to all volumetric parameters. Although the findings indicate the presence of brain atrophy in patients with late-onset depression, the pattern of volumetric changes in these patients differs markedly from that observed in patients with primary degenerative dementia.