RESUMO
The role of functional state of hematoencephalic barrier (HEB) was estimated in terms of development of pathological process in coma. The quantitative determination of neurospecific protein (NSP), exactly of alpha 1 and of alpha 2 cerebral globulins (produced by astrocytes and oligodendroglial cells) was used for estimation of HEB state. The clinical examination of 138 children in comatose state caused by different factor (meningitis, encephalitis, cerebrocranial trauma, infectious toxicosis) was performed. Enzyme immuno-assay of alpha 1 and of alpha 2 cerebral globulins allowed to control HEB's functional state objectively in "brain-blood" direction: in cases of alteration of HEB's function the autoantibodies to NSP may penetrate into cerebral tissue and cause nonspecific reaction in form of edema or inflammation. The membrane stabilizing effect of Dexamethazone was established.
Assuntos
Doenças Autoimunes/metabolismo , Barreira Hematoencefálica , Permeabilidade da Membrana Celular , Coma/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Doença Aguda , Adolescente , Adulto , alfa-Globulinas/análise , alfa-Globulinas/efeitos dos fármacos , alfa-Globulinas/metabolismo , Animais , Doenças Autoimunes/etiologia , Biomarcadores/análise , Barreira Hematoencefálica/efeitos dos fármacos , Permeabilidade da Membrana Celular/efeitos dos fármacos , Criança , Pré-Escolar , Coma/etiologia , Dexametasona/farmacologia , Glucocorticoides/farmacologia , Humanos , Lactente , Recém-Nascido , Proteínas do Tecido Nervoso/análise , Proteínas do Tecido Nervoso/efeitos dos fármacos , Ratos , Fatores de TempoAssuntos
Anormalidades Múltiplas/diagnóstico , Agenesia do Corpo Caloso , Degeneração Macular/diagnóstico , Espasmos Infantis/diagnóstico , Anormalidades Múltiplas/genética , Pré-Escolar , Feminino , Ligação Genética , Humanos , Lactente , Degeneração Macular/genética , Espasmos Infantis/genética , Síndrome , Cromossomo XAssuntos
Encéfalo/anormalidades , Epilepsia/etiologia , Hemiplegia/etiologia , Convulsões/etiologia , Encéfalo/diagnóstico por imagem , Pré-Escolar , Eletroencefalografia , Epilepsia/diagnóstico , Hemiplegia/diagnóstico , Humanos , Masculino , Exame Neurológico , Convulsões/diagnóstico , Síndrome , Tomografia Computadorizada por Raios XRESUMO
The diagnostic value of Lüscher's colour test for the estimation of emotional state of children and juveniles (teenagers) with central nervous system's organic alteration and borderline psychopathological disturbances was analysed. Moreover a number of other additional tests were used namely the colour estimation of current and optimal state, the measurement of personal emotional anxiety according to Scott scale as well as the comparison of colour selection results and colour perception in dream. It was demonstrated that color selection results depended upon both neuroticism level and presence or type of psychopathological disturbances. They had their own specificity if organic CNS alteration took place and were determined by pathological focus localization. The psychological characteristics that were symbolized in colours according to Lüscher corresponded mainly to personal peculiarities in both neurosis-like and certain types of psychopathological alteration in which the definite colours were preferable.
Assuntos
Neoplasias Encefálicas/psicologia , Testes de Percepção de Cores/métodos , Emoções , Epilepsia/psicologia , Transtornos Neuróticos/psicologia , Testes de Personalidade , Adolescente , Neoplasias Encefálicas/diagnóstico , Criança , Percepção de Cores , Epilepsia/diagnóstico , Humanos , Transtornos Neuróticos/diagnóstico , Personalidade , PsicopatologiaRESUMO
Observation's analysis of 5 children in age from 9 months to 4 years 11 months with tuberous sclerosis was performed. The initial manifestations of disease were following: early children form of epilepsy exactly infantile spasms (West syndrome) appearance, dermal alterations in the form of depigmented spots as well as nonprogressive delay in psychoverbal development. Together with clinical symptoms the main criterion in early form of tuberous sclerosis diagnosis determination turned out to be brain's specific alterations (tubers) which were revealed by computer tomography. The correlation was observed between epileptic seizures polymorphism and frequency as well as brain's morphological alterations. Derivatives of valproic acid were the basic drugs in treatment of epileptic seizures in patients.
Assuntos
Espasmos Infantis/diagnóstico , Esclerose Tuberosa/diagnóstico , Anticonvulsivantes/uso terapêutico , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Masculino , Espasmos Infantis/tratamento farmacológico , Espasmos Infantis/genética , Síndrome , Esclerose Tuberosa/tratamento farmacológico , Esclerose Tuberosa/genéticaRESUMO
Patients with Duchenne muscular dystrophy were analyzed using the method of polymerase chain reaction in order to reveal deletions in the dystrophin gene. Deletions of different lengths and locations were detected in 28 of 78 ill boys. The highest number of deletions was detected in the 3'-end of the gene (the 45-50th exons).
Assuntos
Deleção Cromossômica , Distrofias Musculares/genética , Adolescente , Criança , Pré-Escolar , Primers do DNA , Distrofina/genética , Eletroforese em Gel de Poliacrilamida , Éxons/genética , Humanos , Masculino , Dados de Sequência Molecular , Distrofias Musculares/diagnóstico , Reação em Cadeia da Polimerase/métodosRESUMO
The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy. Twelve of them had infantile spasms, four Lennox-Gastaut syndrome. The treatment produced good results in 75% of the patients. Encorat mono- or polychemotherapy is able to discontinue or decrease the frequency of the epileptic fits, improve the patients' condition in resistant early childhood epilepsy.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsia/tratamento farmacológico , Hemiplegia/tratamento farmacológico , Espasmos Infantis/tratamento farmacológico , Ácido Valproico/análogos & derivados , Ácido Valproico/uso terapêutico , Anticonvulsivantes/efeitos adversos , Carbamazepina/uso terapêutico , Pré-Escolar , Clonazepam/uso terapêutico , Quimioterapia Combinada , Epilepsia/diagnóstico , Etossuximida/uso terapêutico , Feminino , Hemiplegia/diagnóstico , Humanos , Lactente , Masculino , Indução de Remissão , Espasmos Infantis/diagnóstico , Síndrome , Fatores de Tempo , Ácido Valproico/efeitos adversosRESUMO
Clinical characteristics of Lyme disease (LD) course in children have been studied. Altogether 86 patients were examined. Serodiagnosis was made in patients basing on indirect immunofluorescence and enzyme immunoassay with LD agent antigens. Erythema--free forms, combination of mite-borne Borrelia infection with tick-borne encephalitis were detected. Two clinicoimmunological LD variants were verified: seropositive and seronegative mite-borne Borrelia infection with typical clinical manifestations. The disease took a benign course responsive to antibiotics in combined treatment of neuromuscular lesions.
Assuntos
Doença de Lyme/complicações , Doenças do Sistema Nervoso/etiologia , Adolescente , Criança , Pré-Escolar , Quimioterapia Combinada , Feminino , Humanos , Lactente , Doença de Lyme/diagnóstico , Doença de Lyme/tratamento farmacológico , Masculino , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/tratamento farmacológico , Estudos Retrospectivos , Testes Sorológicos , Síndrome , Fatores de TempoRESUMO
The dreams were analyzed in 73 patients aged 10-14, among them 22 had brain tumors, 23 epilepsy, 18 neurotic and psychopathic-like disturbances. The control group included 10 healthy children. The results showed that the frequency and pattern of the dreams are related to functional disturbances secondary to the organic lesions of the brain as well as to organic lesions themselves and relevant location. Correlation between dream features and psychologic characteristics of the patients has also been demonstrated.
Assuntos
Doenças do Sistema Nervoso Central/psicologia , Sonhos/psicologia , Adolescente , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/psicologia , Doenças do Sistema Nervoso Central/diagnóstico , Criança , Dominância Cerebral , Epilepsia/diagnóstico , Epilepsia/psicologia , Humanos , Métodos , Testes Neuropsicológicos , Transtornos Neuróticos/diagnóstico , Transtornos Neuróticos/psicologia , PsicopatologiaRESUMO
The paper analyzes the results of studying nervous diseases in children with HIV infection. A total of 57 children aged 1.5 to 16 years who had different stages of AIDS were examined. HIV-related encephalopathy, encephalopathy with the polyneuropathy syndrome, encephalomyelopolyneuritis, mixed AIDS-related encephalopathy and perinatal encephalopathy, as well as the myopathic syndrome were identified. The affliction of the nervous system was more severe with an earlier history of infection. The clinical syndromes were supported by electromyographic indices.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , HIV-1 , Doenças do Sistema Nervoso/etiologia , Complexo AIDS Demência/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/congênito , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Síndrome da Imunodeficiência Adquirida/congênito , Síndrome da Imunodeficiência Adquirida/diagnóstico , Adolescente , Criança , Pré-Escolar , Eletromiografia , Feminino , Humanos , Lactente , Masculino , Doenças do Sistema Nervoso/congênito , Doenças do Sistema Nervoso/diagnósticoRESUMO
Disorders seen in patients with Alzheimer's disease are also related to the pathology of immunity. In order to study it in a more detailed manner, some immunity parameters were examined in 30 patients with Alzheimer's disease, 15 patients with Huntington's chorea which may have similar mechanisms of immunologic defects, and 15 healthy donors. A study was also made of the capacity of peripheral blood lymphocytes to respond to polyclonal mitogens in blast transformation test and according to the production of immunoglobulins in vitro. The subpopulation composition of these cells was investigated as well. A significant rise of the count of C 8+ lymphocytes, depression of proliferative response, low spontaneous and high Phytolacca mitogen-stimulated immunoglobulin production have been revealed. The changes recorded in Huntington's chorea had the same nature of development. The disorders revealed allow a conclusion about an important role that may be played by the immune system in these degenerative diseases of the brain.
Assuntos
Doença de Alzheimer/imunologia , Formação de Anticorpos , Linfócitos B/imunologia , Proteína Glial Fibrilar Ácida/imunologia , Humanos , Doença de Huntington/imunologia , Imunidade Celular , Imunoglobulinas/sangue , Ativação Linfocitária/efeitos dos fármacos , Proteínas da Mielina/imunologia , Linfócitos T/imunologiaAssuntos
Epilepsia/etiologia , Hemiplegia/etiologia , Convulsões/etiologia , Anticonvulsivantes/uso terapêutico , Diagnóstico Diferencial , Epilepsia/diagnóstico , Epilepsia/tratamento farmacológico , Feminino , Hemiplegia/diagnóstico , Hemiplegia/tratamento farmacológico , Humanos , Masculino , Convulsões/diagnóstico , Convulsões/tratamento farmacológico , SíndromeRESUMO
A variety of temporal epilepsy that manifested by paroxysms in the form of psychosensory and gustatory ones is described. A 20-year-old man was placed under observation. Since 14 years of age he demonstrated attack-like conditions with a sensation of the pushing apart and swelling in the head, of an increase of the head size, and unpleasant sickly sweet taste in the mouth. The attacks were accompanied by anxiety and general weakness. Neurological examination revealed left-handed hemisymptomatology, EEG demonstrated activity prevailing in the occipitotemporal leads on the right. The neuropsychological findings attested to the impairment of the structures of the right temporal lobe. Analysis of the clinical manifestations of epilepsy, of the neurological findings, and the neuropsychologist's conclusion made it possible to suggest the site of the epileptic focus in the field of the hippocamp on the right.