[Multimodal therapeutic strategies in the treatment of cerebrovascular disease]. / Mul'timodal'nye terapevticheskie strategii v lechenii tserebrovaskulyarnoi bolezni.

The review presents the scientific substantiation of the relationship between age-related cerebrovascular changes and dysregulation of cerebral perfusion, blood-brain barrier (BBB) function and neurovascular units. The ischemic cascade in cerebrovascular disease (CVD) is considered, the main links of which are glutamate excitoxicosis, oxidative stress and neuroinflammation. Endothelial dysfunction and increased BBB permeability play an important role in the development of neuroinflammation. The use of multifunctional drugs aimed at various pathological targets of acute and chronic cerebral ischemia for the purpose of neuroprotection has been substantiated. These drugs include the peptide Cortexin (cattle cerebral cortex polypeptides). Experimental data on the study of its molecular partners in the brain are presented. The clinical efficacy of Cortexin as a neuroprotective drug in CVD has been established in many studies.

[Review of clinical guidelines for the treatment and prevention of ischemic stroke]. / Obzor klinicheskikh rekomendatsii lecheniia i profilaktiki ishemicheskogo insul'ta.

One of the leading causes of death, disability and severe maladaptation of patients is ischemic stroke, which accounts for about 80% of all types of acute cerebrovascular accidents. At the same time, approximately 2/3 of the patients show residual effects of cerebral circulation disorders of varying severity. Currently, the problem of ischemic stroke attracts great attention and international and domestic recommendations developed for the prevention, treatment and rehabilitation of stroke patients are one of the aspects of work in this area. The article provides an overview of the latest clinical guidelines for the early management of patients with acute ischemic stroke of the American Heart Association and the American Stroke Association, as well as features of stroke therapy and prevention in Russia, Europe and USA.

[The effect of cholesterol on the electrokinetic properties of erythrocyte membranes in chronic cerebral ischemia]. / Vliianie kholesterina na élektrokineticheskie svoĭstva membran éritrotsitov pri khronicheskoĭ ishemii golovnogo mozga.

AIM: To determine the effects of total plasma cholesterol on the electrokinetic properties of erythrocyte membranes of healthy volunteers and patients with chronic cerebral ischemia (CCI). MATERIAL AND METHODS: Authors studied the erythrocytes from venous blood of 95 patients with CCI and 54 healthy people (controls). To perform an electrophoretic cell analysis of erythrocytes, we used the shorthand method of computer microelectrophoresis. RESULTS AND CONCLUSION: Plasma cholesterol level increased with the age. In the control group, there were the increase in percentage of fixed red blood cells, decrease in the amplitude of oscillations and electrophoretic mobility of red blood cells. In CCI patients, a significant increase in the share of fixed red blood cells, decrease in the amplitude of oscillations and electrophoretic mobility were observed compared to the controls. An increase in percentage of fixed red blood cells as well as in the qualitative heterogeneity of red blood cells in the amplitude of the oscillations was identified both in patients and controls, regardless of sex and age, with higher levels of total cholesterol.