Multiple sclerosis imaging in clinical practice: a European-wide survey of 428 centers and conclusions by the ESNR Working Group.

OBJECTIVES: To evaluate compliance with the available recommendations, we assessed the current clinical practice of imaging in the evaluation of multiple sclerosis (MS). METHODS: An online questionnaire was emailed to all members and affiliates. Information was gathered on applied MR imaging protocols, gadolinium-based contrast agents (GBCA) use and image analysis. We compared the survey results with the Magnetic Resonance Imaging in MS (MAGNIMS) recommendations considered as the reference standard. RESULTS: A total of 428 entries were received from 44 countries. Of these, 82% of responders were neuroradiologists. 55% performed more than ten scans per week for MS imaging. The systematic use of 3 T is rare (18%). Over 90% follow specific protocol recommendations with 3D FLAIR, T2-weighted and DWI being the most frequently used sequences. Over 50% use SWI at initial diagnosis and 3D gradient-echo T1-weighted imaging is the most used MRI sequence for pre- and post-contrast imaging. Mismatches with recommendations were identified including the use of only one sagittal T2-weighted sequence for spinal cord imaging, the systematic use of GBCA at follow-up (over 30% of institutions), a delay time shorter than 5 min after GBCA administration (25%) and an inadequate follow-up duration in pediatric acute disseminated encephalomyelitis (80%). There is scarce use of automated software to compare images or to assess atrophy (13% and 7%). The proportions do not differ significantly between academic and non-academic institutions. CONCLUSIONS: While current practice in MS imaging is rather homogeneous across Europe, our survey suggests that recommendations are only partially followed. CLINICAL RELEVANCE STATEMENT: Hurdles were identified, mainly in the areas of GBCA use, spinal cord imaging, underuse of specific MRI sequences and monitoring strategies. This work will help radiologists to identify the mismatches between their own practices and the recommendations and act upon them. KEY POINTS: • While current practice in MS imaging is rather homogeneous across Europe, our survey suggests that available recommendations are only partially followed. • Several hurdles have been identified through the survey that mainly lies in the areas of GBCA use, spinal cord imaging, underuse of specific MRI sequences and monitoring strategies.

Diffusion tensor imaging MR neurography in patients with acute or chronic plexopathy.

The nerve plexus is susceptible to various pathological processes. In addition to clinical and electrophysiological findings, magnetic resonance neurography (MRN) may contribute to characterize plexus involvement. Diffusion tensor imaging (DTI) was reported feasible for the nerve plexuses imaging but its value in the clinical practice remains uncertain. From 2014 to 2020, we routinely performed MRN including DTI at 3T in patients with acute or chronic plexopathy. DTI images were co-registered with conventional MRN images. MRN images including DTI were reviewed by consensus by two neuroradiologists and one neurologist. They retrospectively identified cases for whom the use of DTI had a potential impact on the diagnostic workup, seven of these clinical cases are presented here. Compared to conventional MRN, the added value of DTI consisted in: (i) improved detection of signal/morphological abnormalities of the plexus (due to removal of background structures, multiplanar reformatted views and large field of view), (ii) additional information regarding the microarchitecture of nerve fibers provided by DTI metrics, (iii) potential alternative for the use of gadolinium. This case series supports the implementation of DTI in MRN protocols.

Jugular venous reflux may mimic type I dural arterio-venous fistula on arterial spin labeling magnetic resonance images.

PURPOSE: Previous studies have shown that arterial spin-labeling (ASL) has high sensitivity and specificity for detecting dural arteriovenous fistulas (DAVFs). However, in case of jugular venous reflux (JVR), the labeled protons in the jugular vein may lead to a venous hypersignal in the jugular vein, sigmoid, and transverse sinus on ASL images and mimic DAVF. METHODS: To ascertain this hypothesis, two blinded senior neuroradiologists independently and retrospectively reviewed randomized ASL images and graded the likelihood of DAVF on a 5-point Likert scale in 2 groups of patients: (i) 13 patients with angiographically proven type I DAVF; and (ii) 11 patients with typical JVR diagnosed on the basis of clinical and MR imaging data, first using ASL alone, and second using ASL together with all of the sequences including 4D CE MRA. RESULT: A dural venous ASL signal was seen in 11 patients with type I DAVF and in all the 11 patients with JVR, with no distinctive pattern between the two. The mean Likert score was "very likely" in DAVF and JVR patients when using ASL alone (k = 0.71), and "very unlikely" for JVR versus "very likely" for DAVF when using all the sequences available (k = 0.92). CONCLUSION: Our study shows that JVR can mimic DAVF on ASL images with potential implications for patient care. The detection of DAVFs should be based on additional MR sequences such as TOF-MRA and 4D CE MRA to exclude JVR and to avoid unnecessary DSAs.

Breath-hold compressed-sensing 3D MR cholangiopancreatography compared to free-breathing 3D MR cholangiopancreatography: prospective study of image quality and diagnostic performance in pancreatic disorders.

PURPOSE: To compare image quality and diagnostic performance of three magnetic resonance cholangiopancreatography (MRCP) protocols in patients with suspected pancreatic abnormalities: free-breathing standard 3D-MRCP (STD), free-breathing compressed sensing 3D-MRCP (CS), and CS 3D-MRCP with acquisition during a single breath-hold > 20 s (BH-CS). METHODS: Informed consent was obtained. We performed 57 MRCPs in 56 prospectively included patients (29 men, median age 59 years). The three protocols were performed in random order. Acquisition time was recorded. Two radiologists blinded to the protocols used 5-point scales to assess image quality parameters (overall image quality, amount of artifacts, background suppression, bile and pancreatic duct visualization) and diagnostic performance (anatomical variants, duct abnormalities, cystic lesions). RESULTS: Acquisition time was 279 s with STD, 176 s with CS (-37%), and 22 s with BH-CS (-93%). STD and BH-CS were not significantly different for overall image quality, artifacts, or background suppression. The BH-CS group had fewer non-diagnostic scans (3% vs. 19% with STD and 21% with CS, p < 0.05), higher-quality scans (78% vs. 66% with STD and 58% with CS, p < 0.05), and milder artifacts (2% vs. 18% with STD and 16% with CS, p < 0.05). The main pancreatic duct was better visualized with BH-CS compared to STD (p = 0.015) and CS (p < 0.001). Diagnostic performance did not differ across the three protocols. There were fewer indeterminate scans in the BH-CS group. CONCLUSION: 3T BH-CS is reliable, saves time, and is not associated with decreases in image quality or diagnostic performance compared to STD and CS.

Revised Atlanta classification for CT pancreatic and peripancreatic collections in the first month of acute pancreatitis: interobserver agreement.

PURPOSE: To assess interobserver agreement when using the revised Atlanta classification (RAC) to categorize pancreatic and peripancreatic collections during the first month of acute pancreatitis (AP), and to correlate type of collection to outcome. MATERIAL AND METHODS: This retrospective study of 115 consecutive patients admitted for 123 AP episodes, 178 CTs performed within the first month showed peripancreatic abnormalities. Each AP episode was classified as mild, moderately severe, or severe based on the RAC. Two radiologists, blinded to clinical data, used RAC criteria to retrospectively categorize the collections as acute peripancreatic fluid collections (APFC) or acute necrotic collections (ANC). Interobserver agreement was assessed based on Cohen's κ statistics and compared according to CT timing. RESULTS: Interobserver agreement for categorizing peripancreatic collections was moderate (κ = 0.45) and did not improve with time to CT (κ values, 0.53 < day 3, 0.34 on days 3-6, and 0.43 ≥ day 7). For detecting parenchymal necrosis, interobserver agreement was also moderate (κ = 0.45). AP was less severe in patients with APFC versus ANC (p = 0.04). CONCLUSION: Our finding of moderate interobserver agreement when using the RAC to categorize pancreatic and peripancreatic collections by CT indicates that the accurate diagnosis of APFC or ANC by CT in the first 4 weeks after symptom onset is often challenging. KEY POINTS: • Interobserver agreement was moderate for categorizing peripancreatic collections. • Interobserver agreement did not improve with time from onset to CT. • Interobserver agreement was moderate for detecting parenchymal necrosis.