RESUMO
The effect of heparine and streptokinase on the indices of hemostasis and fibrinolysis was studied in 74 patients with different clinical variants of chronic glomerulonephritis. Differences were shown in changes of hemocoagulation and fibrinolytic potentials of the blood depending both on the nature of the employed medicinal agent and on the initial level of blood coagulation and fibrinolysis.
Assuntos
Transtornos da Coagulação Sanguínea/tratamento farmacológico , Glomerulonefrite/complicações , Heparina/uso terapêutico , Estreptoquinase/uso terapêutico , Terapia Trombolítica , Adolescente , Adulto , Transtornos da Coagulação Sanguínea/sangue , Transtornos da Coagulação Sanguínea/etiologia , Doença Crônica , Fibrinólise/efeitos dos fármacos , Glomerulonefrite/sangue , Glomerulonefrite/tratamento farmacológico , Hemostasia/efeitos dos fármacos , Humanos , Hipertensão Renal/sangue , Hipertensão Renal/complicações , Hipertensão Renal/tratamento farmacológico , Pessoa de Meia-Idade , Síndrome Nefrótica/sangue , Síndrome Nefrótica/complicações , Síndrome Nefrótica/tratamento farmacológicoRESUMO
In 161 patients with acute myocardial infarction, the kallikrein-kinin system was found to be activated. In addition, there were alterations in indices of the coagulative system, which were suggestive of hypercoagulation. The unidirectional changes in the indices of the systems in question during therapy in the periods of rehabilitation are attributable to the common character of trigger mechanisms responsible for their activation and to the involvement of the kinin system in the regulation of hemostatic potential.
Assuntos
Calicreínas/sangue , Cininas/sangue , Infarto do Miocárdio/sangue , Adulto , Idoso , Hidrolases de Éster Carboxílico/sangue , Ativação Enzimática , Feminino , Humanos , Lisina Carboxipeptidase/sangue , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/reabilitação , Peptidil Dipeptidase A/sangue , alfa 1-Antitripsina/análiseRESUMO
The kinin and coagulation functions were examined in 78 myocardial infarction patients in relation to the presence of essential hypertension. The kallikrein-kinin activation and blood hypercoagulation were shown to be more pronounced in cases of associated essential hypertension.