RESUMO
Inflammatory bowel diseases are associated with a state of hypercoagulability secondary to several mechanisms, protein S deficiency being one of these. It can be revealed by spontaneous skin necrosis in children. This condition is rare in adults with Crohn's disease. We are reporting a case of a 35-year-old woman with active Crohn's disease who presented a protein S deficiency responsible for an extensive spontaneous skin necrosis. The evolution was favourable after vascular filling, curative anticoagulation, antibiotic therapy, as well as a high-dose of corticosteroid therapy. We are reporting this case in order to emphasize the importance of considering skin necrosis as a possible cutaneous manifestation of inflammatory bowel diseases.
Assuntos
Doença de Crohn/complicações , Deficiência de Proteína S/complicações , Dermatopatias/etiologia , Pele/patologia , Corticosteroides/administração & dosagem , Adulto , Antibacterianos/administração & dosagem , Anticoagulantes/administração & dosagem , Doença de Crohn/diagnóstico , Doença de Crohn/tratamento farmacológico , Feminino , Humanos , Necrose , Deficiência de Proteína S/diagnóstico , Deficiência de Proteína S/tratamento farmacológico , Pele/efeitos dos fármacos , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia , Resultado do TratamentoRESUMO
Meningioma rarely gives rise to metastases outside the brain and meninges. We report here a case of a patient who was treated for anaplastic brain meningioma with surgery and fractionated radiation therapy without any recurrence until 5 years after the operation, when she developed vertebral metastases.
