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ACS Macro Lett ; 11(9): 1129-1135, 2022 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-36044353

RESUMO

Naturally abundant polyphenols that can readily undergo the facile cross-linking of polymer chains have been of great interest for functional hydrogel formation and its potential biomedical applications. Herein, we report that the internal incorporation of tannic acid (TA) as a natural polyphenol additive at the chitosan-based nanogel templates can enhance the self-association of physically cross-linked polymer networks upon dilution, as well as the colloidal gel stability in protein solution. This is driven by the multivalent hydrogen bonding and π-stacking capability of TA, as verified by the viscosity estimation of diluted nanogel solution, coupled to the conformation-dependent excimer emission of stacked fluorophores in polymer networks, which also allows for the Stern-Volmer analysis of the TA-induced quenching property. Furthermore, the excellent coordination generality of TA for versatile metallic cations enables the facile immobilization of a cisplatin pharmacophore inside the nanogels for acid-sensitive drug release and the potential delivery of metallic components.


Assuntos
Quitosana , Polifenóis , Cisplatino , Hidrogéis , Nanogéis , Polietilenoglicóis , Polietilenoimina , Polímeros , Taninos
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