[Molecular mechanisms of hypothalamic hexapeptide regulation of the links in glycogen metabolism]. / Molekuliarnye mekhanizmy reguliatsii gipotalamicheskim geksapeptidom nekotorykh zven'ev obmena glikogena.

Alterations in content of glycogen as well as in activity of phosphorylase and phosphoprotein phosphatase were studied in various rat tissues after intravenous administration of a new hypothalamic hexapeptide Tyr-Gly-Leu-Pro-Gly-NH2. An increase in phosphoprotein phosphatase activity was observed in heart muscle, which correlated with transformation of phosphorylase A to the B form and with accumulation of glycogen. The opposite effect was found in liver tissue and sceletal muscle.