Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors.

Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings. Both receptors and the thyroid-stimulating hormone receptor are members of a subset of G-protein coupled receptors (GPCRs) described as the glycoprotein hormone receptors. Their ligands, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and a structurally related hormone produced in pregnancy, human chorionic gonadotropin (hCG), are large protein hormones that are extensively glycosylated. Although the primary physiologic functions of these receptors are in ovarian function and maintenance of pregnancy in human females and spermatogenesis in males, there are reports of LHRs or FSHRs involvement in disease processes both in the reproductive system and elsewhere. In this review, we evaluate the aggregation state of the structure of actively signaling LHRs or FSHRs, their functions in reproduction as well as summarizing disease processes related to receptor mutations affecting receptor function or expression in reproductive and non-reproductive tissues. We will also present novel strategies for either increasing or reducing the activity of LHRs signaling. Such approaches to modify signaling by glycoprotein receptors may prove advantageous in treating diseases relating to LHRs or FSHRs function in addition to furthering the identification of new strategies for modulating GPCR signaling.

Risk-taking, attitudes toward aggression, and aggressive behavior among rural middle school youth.

This study examined the relationship between risk-taking, general acceptance of aggression (GAA), verbal harassment (VH), and aggressive behavior (AB) in the last 30 days among 1440 seventh- and eighth-grade rural middle school youth. Higher levels of risk-taking predicted higher GAA and VH. Significant interactions for AB indicated that, excepting Black youth, higher risk-taking was related to higher levels of violent behavior. Among Black youth the highest levels of AB occurred at moderate levels of risk-taking. Level of risk-taking is an important risk factor that should be taken into account in the study of attitudes toward aggression and aggressive behavior among rural youth.