1.
Chem Commun (Camb)
; 51(59): 11783-6, 2015 Jul 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26107990
RESUMO
The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of benzylic C-H bonds provides a means to attenuate drug metabolism at this metabolically labile position. Here we report two complimentary strategies for the direct fluorination of benzylic C-H bonds using N-fluorobenzenesulfonimide and either a decatungstate photocatalyst or AIBN-initiation.