RESUMO
The data on cytogenetic examination concerning the offspring of the Chernobyl accident liquidators (cleanup personnel) have been obtained. It has been established that spontaneous chromosomal aberrations level before folic acid administration was 1,8 times higher than that value after its employment (4,45 to 2,42 %, p < 0,01). In lymphocyte cultures treated with mitomycin C accompanied by folic acid it was 4,5 times higher before their administration (23,95 to 5,36 %, p < 0,001). The data obtained confirm a possibility of stabilization of genetic apparatus in offspring of the Chernobyl disaster liquidators after folic acid administration.
Assuntos
Acidente Nuclear de Chernobyl , Aberrações Cromossômicas , Ácido Fólico/farmacologia , Leucócitos Mononucleares/patologia , Militares , Exposição Ocupacional , Adolescente , Células Cultivadas , Criança , Aberrações Cromossômicas/efeitos dos fármacos , Doença Crônica , Análise Citogenética , Feminino , Ácido Fólico/uso terapêutico , Gastroenteropatias/genética , Gastroenteropatias/prevenção & controle , Humanos , Masculino , Mitomicina/farmacologia , Neurastenia/genética , Neurastenia/prevenção & controle , Exposição PaternaRESUMO
The paper submits data on the antigenic composition of HLA system in members of nuclear families of adolescent boys presenting with the delay in sexual maturation. Positive and negative associations of particular antigens with sexual underdevelopment are stated. Estimated in the families was the highest incidence rate of gaplotypes A 28-B 40, A 28-B 8, A 1-B 40, and A 3-B 40. The authors come out with a suggestion that it might be possible to use the identified antigens in prognostication of delayed puberty.
Assuntos
Antígenos HLA/genética , Núcleo Familiar , Puberdade Tardia/genética , Adolescente , Adulto , Feminino , Frequência do Gene , Haplótipos , Humanos , Masculino , Pessoa de Meia-Idade , Puberdade Tardia/imunologia , UcrâniaRESUMO
Frequency distribution of HLA antigens of A and B loci was examined in 138 adolescent boys aged 14-18 with delayed sexual development (DSD) of stages I-III, residing in the north-eastern region of Ukraine. Increase of A28- and B40-antigens and haplotypes A1-B40, A28-B40, A10-B40 determination frequencies was established. There were revealed positive and negative correlation between some of HLA antigens and DSD. Relative and attributive risks of DSD formation were calculated.
