RESUMO
A simple and efficient synthesis of N-cyclohexyl-benzofuran derivatives was achieved via a one-pot three-component reaction of cyclohexylisocyanide, an aromatic aldehydes, and phenols in DMF for 10 h with good yields.
Assuntos
Benzofuranos/química , Benzofuranos/síntese química , Indicadores e Reagentes/química , Indicadores e Reagentes/economia , CinéticaRESUMO
Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.
Assuntos
Furanos/síntese química , Química Verde/métodos , Água/química , Aldeídos/química , Cianetos/química , Ciclização , Cicloexanos/química , Furanos/química , Indanos/química , TemperaturaRESUMO
A high yielding and fast method for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine via one-pot, three component reaction of an aromatic aldehyde, isocyanide and o-aminophenol using p-toluene sulfonic acid as a catalyst is described.
