Does sex affect the efficacy of systemic pharmacological treatments of pain in knee osteoarthritis? A systematic review.

Objective: To determine whether sex influences the analgesic efficacy of systemic pharmacological treatment in patients with knee osteoarthritis. Design: A systematic review, guided by Cochrane methods, sourced studies from Medline, Cochrane Library, Embase, and CINAHL Plus with Full Text as of October 10, 2022. Eligible studies were double-blind RCTs evaluating systemic pharmacological treatments for knee osteoarthritis in adults, with minimum 30-day treatment duration, reporting sex-specific results or mentioning sex subgroup analysis for analgesic efficacy. The risk of bias was assessed using the Cochrane Risk of Bias tool version 2 (RoB 2). Results: 9 studies (5201 participants) met inclusion criteria, analyzing drugs including duloxetine, etoricoxib, tapentadol, naproxcinod, lutikizumab, and rofecoxib. Only one study reported sex-specific results. Review findings suggested no significant sex-based differences in treatment efficacy, however, data were limited due to a lack of sex-specific reporting or inclusion of sex in subgroup analyses. Conclusions: Current evidence does not support the existence of sex differences in the analgesic efficacy of systemic knee osteoarthritis treatments. However, this conclusion is substantially limited by the paucity of sex-specific reporting of results or subgroup analyses in most primary studies, emphasizing the need for future research to report on sex-stratified data to allow for comprehensive, personalized treatment strategies.

Electrodiagnostic Findings in 441 Patients with Ulnar Neuropathy - a Retrospective Study.

PURPOSE: Ulnar neuropathy (UN) is the second most common focal neuropathy in the upper extremities. Electrodiagnostic studies (EDx), including nerve conduction study (NCS) and electromyography (EMG), are reliable tools for the diagnosis of ulnar neuropathy. We aimed to retrospectively analyze the medical records of patients diagnosed with ulnar neuropathy in a seven-year period and report our findings. PATIENTS AND METHODS: In this retrospective study, documents of the patients whose ulnar nerve injury was confirmed through electrodiagnostic study in two departments of Physical Medicine and Rehabilitation were collected and demographic data, subjective complaints of the patient, the cause, and electrodiagnostic findings were extracted from each patient's file. The following points were specifically evaluated in the electrodiagnostic records; type of injury, location, accompanying injuries, sensory nerve action potentials (SNAP) of the fifth finger, SNAP of dorsal ulnar cutaneous nerve (DUCN), compound muscle action potential (CMAP) of abductor digiti minimi (ADM) muscle, nerve conduction velocity (NCV) across elbow, patterns of muscle involvement, and the severity of insult. RESULTS: Out of 441 records, 305 (69.2%) were male and 68.1% were non-traumatic. Based on our clinical criteria, the intensity of the injury was mild in most cases. The elbow and forearm were the most involved regions in non-traumatic and traumatic cases respectively. Across elbow nerve conduction velocity showed decreased velocity in 71% of records. In non-traumatic cases, the most affected muscle was ADM (97%) and then FDI (85%). CONCLUSION: In focal entrapments such as ulnar neuropathy, electrodiagnostic findings are very helpful in assessing location, severity, and type of injury. If a consensus is achieved for the diagnosis of UN, even retrospective studies can become valuable sources for studying UN.

Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial.

BACKGROUND: Carpal tunnel syndrome is the most common peripheral entrapment neuropathy, for which conservative treatments are the first measures taken. However, these measures are not usually sufficient. Recently major attention has been drawn to platelet-rich plasma for its possible effects on axon regeneration and neurological recovery. Although few studies have evaluated the effects of this treatment in carpal tunnel syndrome, further investigation is required to reach concrete conclusion. METHODS: In this randomized controlled trial, women referring to the physical medicine and rehabilitation clinic at Shahid Modarres Hospital during 2016 with a diagnosis of mild and moderate idiopathic carpal tunnel syndrome were chosen. They were randomly assigned to two groups: (i) a control group using only a wrist splint, and (ii) a platelet-rich plasma group that received wrist splints along with a single local injection of platelet-rich plasma. The outcome measures were assessed via Visual Analogue Scale, the Boston Carpal Tunnel Syndrome Questionnaire and electrophysiological findings including the peak latency of sensory nerve action potential and the onset latency of the compound muscle action potential. RESULTS: A total of 41 women were included (20 wrists as control group) and (21 wrists as platelet-rich plasma group). Before treatment there were no significant differences between the two groups except for the median peak latency of sensory nerve action potential which was significantly higher among the patients in the platelet-rich plasma group (p = 0.03). All the measured variables significantly decreased in both groups after 10 weeks of treatment except for the median onset latency of the compound muscle action potential (p = 0.472). Finally, the changes in neither of the evaluated outcome measures were found to significantly differ between the two groups, even when the analyses were adjusted for age of the patients. CONCLUSION: The findings of this study showed that in a relatively short period of time after treatment, a single injection of platelet-rich plasma in the wrist does not significantly add to the effects of conservative treatment with wrist splints, in regards to the women pain and symptom severity, functional status and electrophysiological parameters. TRIAL REGISTRATION: The trial has been retrospectively registered with an ID: IRCT2017041513442N13 (Date of registration: 2017-06-19).

Development of a scale for measuring social health of Iranians living in three big cities.

BACKGROUND: Social health is considered as a significant dimension of health and, hence, its assessment is vital in health planning. Within this context, this study aimed to develop a valid and reliable scale for measuring individual's social health in Iran. To do so, an exploratory sequential mixed method was used. METHODS: To establish the item pool and primary scale, 30 interviews with experts and other stakeholders, and a primary review of relevant literature and similar questionnaires were conducted. Then, a survey with 800 respondents from three cities in Iran was undertaken to assess the validity and reliability of the scale. RESULTS: In the qualitative stage of this study, after careful consideration, forty questions were remained for the next step. Considering the correlation of the score of each question with the total score of the questionnaire, seven questions were omitted. For this questionnaire with 33 remaining questions, Cronbach's alpha for internal consistency was estimated to be 0.86. The reliability coefficient for 100 samples (taken after 7 to 10 days from the first round of sampling) was 0.91. Considering the factor analysis, three factors were recognized. These factors were named as "family", "community" and "friends and relatives". Cronbach's Alpha for internal consistency of community, friends and relatives, and family factors were estimated to be 0.91, 0.77 and 0.78 respectively. The corresponding value of the reliability indicator, intraclass correlation coefficient (ICC), for community, friends and relatives, and family were calculated 0.69, 0.80 and 0.67 respectively. CONCLUSION: We developed a measurable scale for social health at an individual level in the Iranian community with an acceptable level of validity and reliability. The new developed scale is able to provide an opportunity to measure Iranians' social health at an individual level. Such an indicator of individual health can be used in evaluating the performance of social health policies and providing a platform for evidence-based policy-making in the social health context.